About this Research Topic
Although the mechanisms of AIT are not completely understood, several approaches aiming at enhancing therapeutic efficacy have been developed or are in the scientific pipeline. Amongst others, these therapeutic concepts include the use of novel adjuvants and other substances with immunomodulatory properties, recombinant engineered allergens or novel routes of application. An important and challenging topic is the development of advanced preventive strategies that are able to induce immunological tolerance to allergens before disease manifestation. Moreover, novel diagnostic concepts including component-resolved IgE-diagnosis, single- and multiplex testing or basophil activation testing play an important role in precisely diagnosing and treating allergies. Additionally, biomarkers that allow predicting severe reactions or therapeutic success are strongly needed for patient stratification and optimal therapeutic intervention.
In this Research Topic, we welcome Reviews, Mini-Reviews, Methods Articles and Original Articles that deal with current state-of-the-art concepts, the latest developments and further perspectives in therapy and diagnosis of allergic diseases. Moreover, actual basic research topics that help to understand the mechanisms of allergy and immunological tolerance and, thus, will help to develop future preventive, therapeutic and diagnostic strategies are highly welcome. More specifically, topics of interest include, but are not limited to:
• Adjuvants, immunomodulators, recombinant allergens and novel routes for allergen immunotherapy
• Biologicals such as antibodies for the treatment of allergy
• Personalized therapy concepts
• Preventive strategies for allergy development, new findings from epidemiologic studies
• Biomarkers in allergy; biomarkers for severe reactions and therapeutic success
• Antibody-allergen interaction; role in disease progression or tolerance induction
• Novel diagnostic approaches; component-resolved diagnostics, single- and multiplex testing; basophil activation testing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.