Helminth infection is well known to elicit strong type-2 responses, both innate and adaptive, at local and distal sites to the parasites themselves. Alongside this, the induction of regulatory immune responses has led to a significant effort to identify particular immunomodulatory helminth products and to assess the effect of helminth infection on the microbiome, on concurrent infections and on inflammatory disease phenotypes. Indeed, research into the impact of live helminth therapy is ongoing across the globe.

Conversely, with a large number of people still suffering the detrimental effects of helminth infection on health, development and economic well-being, efforts into the development of vaccines/effective medications to eliminate these infections are pertinent.

Building on several decades of helminth immunology research, the field is ever-expanding, and recent technological developments are allowing a more detailed and in-depth analysis of the immune responses elicited by helminth infections. It is also apparent that helminth infection can be used as a useful tool to explore areas previously understudied by immunologists and allow cross-talk between traditionally separate research areas, including nutrition, metabolism and the nervous system.

In this Research Topic, we aim to explore recent cutting-edge research covering the broad field of helminth immunology. We welcome the submission of Original Research articles, Reviews, Methods and Perspectives focusing on the following subtopics:

• The immune interface between parasite and host (in model animal and human infection settings).
• Immunomodulation by helminths and the identification of novel molecular helminth products with their impact on bystander responses.
• Immunological outcomes of clinical trials and helminth-associated therapies.

Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

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