The RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) Framework, introduced in 1999, is a robust model used for intervention planning and evaluation. It has been widely adopted within the US and internationally, across such fields as public health, health care, behavioral science, and education. RE-AIM is considered a pragmatic, unifying model to foster inter-disciplinary collaboration across fields that traditionally vary in their measures, methodologies, and processes. While much is known about the history and application of RE-AIM over the past 20 years, additional efforts are needed to: (1) document lessons learned, adaptations, types of utilization, and innovative uses; and (2) identify the framework’s potential to advance science, quality of practice, and population health.

To enhance our understanding about the use and application of RE-AIM in research and practice, articles about the following topics will be considered, as well as author proposed topics related to the overall theme:
• Applications for any of the following: intervention planning and development; planning, development, and tailoring of implementation strategies; understanding, assessing and guiding adaptations; and sustainability
• Use for behavioral, environmental, healthcare, and policy change and new areas of application (e.g., precision medicine; communication and marketing; shared decision making or health economics; climate change; technology and big data; learning health systems)
• Mixed-methods approaches with attention to both quantitative and qualitative approaches to provide summary score(s) and profiles for different dimensions
• Use for diverse populations (e.g., across the life-course) and settings (e.g., global health, schools, communities)
• Applications in unique international settings and different cultural contexts
• Critiques about the strengths and weaknesses of the model (theoretical and applied)
• Integration of RE-AIM with other explanatory and process models, theories, or frameworks
• Integration of RE-AIM with other research guidelines and reporting recommendations

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Frontiers in Public Health

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