Contraceptive pills might impair fear-regulating regions in women’s brains

by Deborah Pirchner, Frontiers science writer Image: Shutterstock.com Fluctuations in sex hormones influence brain activity of the fear circuitry. A team of researchers in Canada has now examined the effects of oral contraceptive (OC) use on women’s brains. Their findings showed that ventromedial prefrontal cortex (vmPFC) thickness of women who were using OCs was reduced compared to men, suggesting a mechanism on how OC use could impair emotion regulation in women. Based on this study, this effect appears to be reversible after discontinuing use. More studies on impact and reversibility are needed, the researchers cautioned. More than 150 million women worldwide use oral contraceptives. Combined OCs (COCs), made up of synthetic hormones, are the most common type. Sex hormones are known to modulate the brain network involved in fear processes. Now a team of researchers in Canada has investigated current and lasting effects of COC use, as well as the role of body-produced and synthetic sex hormones on fear-related brain regions, the neural circuitry via which fear is processed in the brain. “In our study, we show that healthy women currently using COCs had a thinner ventromedial prefrontal cortex than men,” said Alexandra Brouillard, a researcher at Université du Québec […]