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29 Mar 2019

New drug resistance process found in bacteria

This is the research team in charge of the study. From left to right: Ivan Erill, Pilar Cortés, Jordi Barbé and Miquel Sánchez-Osuna. Credit: UAB. — by Autonomous University of Barcelona A team of researchers has discovered a new process capable of generating resistance to synthetic antibacterial drugs within bacterial populations long before they are put to clinical use. The research was led by Jordi Barbé, researcher at the Molecular Microbiology Group of the Universitat Autònoma de Barcelona (UAB), and by Ivan Erill from the Department of Biology at the University of Maryland, Baltimore County (UMBC). The findings were recently published in the journal Frontiers in Microbiology. Researchers analysed the large volume of bacterial genomes available with the aim of identifying the origin of mobile genetic elements carriers of a resistance to sulfonamides frequently detected in the superbacteria found in hospitals. Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates► Read original article► Download original article (pdf) Through a comparative analysis of sequences and phylogenetic techniques, the researchers were able to establish that sulfonamide-resistant genes appeared in two ground bacteria families (Rhodobiaceae and Leptospiraceae) over 600 million years ago thanks to a mutation in the drug’s target gene. The […]

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