Formula-fed or cesarean-delivered infants showed altered trajectories of colonization among bacterial families that have been linked to food allergies, as well as rapid weight gain. Image: Shutterstock.

Formula feeding and delivery by Cesarean section affect the development of the gut microbiome in infants

— By KED Coan

Formula-fed or cesarean-delivered infants had different trajectories of gut bacterial colonization in later infancy compared to vaginally born and breastfed infants, finds a study in open-access journal Frontiers in Pediatrics. This could have implications for their future health.

First year of life is critical

The first year of an infant’s life is a critical time for the development of his or her gut microbiome — the more than 1,000 types of bacteria that live in the intestines. These bacteria not only help infants digest food, but they also “train” their developing immune system.

An infant’s environment is the biggest factor in determining which bacteria are present, and so changes such as the type of birth and food, as well as early use of antibiotics, can have a big impact on the infant’s growing gut microbiome. But, researchers are still working to understand exactly what these differences are, and what they could mean for an infant’s future health.

Cesarean delivery and formula feeding lead to differences in gut biome

“Our goal was to characterize the combined influence of cesarean delivery, antibiotic treatment, and formula-feeding on the development of gut microbiota in infants,” says Anita Kozyrskyj, a researcher at the University of Alberta, Canada, and the group leader of the study. “We found that, compared to vaginally-born and breastfed infants, formula-fed or cesarean-delivered infants had different trajectories of bacterial colonization in later infancy, which could have implications for their future health.”

Kozyrskyj and her collaborators used a method — called Significance Analysis of Microarrays — to quantify changes to gut bacteria in 166 infants through the first year of their lives. Other researchers have already shown that there are typical patterns in the types of bacteria that inhabit a growing infant, but Kozyrskyj’s work is among the first to study the rates of colonization for each type of bacteria with infant age — highlighting which bacteria dominate as the gut microbiome evolves over time.

Changes in bacterial families linked to food allergies and weight gain

Kozyrskyj’s group found that, compared to the normal progression of gut bacteria with infant age, formula-fed or cesarean-delivered infants showed altered trajectories of colonization among the bacterial families that have been linked to food allergies, as well as rapid weight gain.

Future research and larger studies will be needed to fully understand the consequences of these changes, but numerous other studies have suggested potential links between these bacteria and the future health of the child — particularly in the development of food allergies.

“We hope this research will help clinicians and parents understand that cesarean section increases the chance of antibiotic treatment or formula-feeding of newborns, which can affect the development of gut microbiota in later infancy,” says Kozyrskyj.

Original research article: Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy

Corresponding author: Anita Kozyrskyj

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