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11 news posts in Pediatrics

Health

26 May 2016

Drug tolerance a problem for hospitalized babies

By Alice R Jensen, Frontiersin.org Research is underway to stop newborn babies from becoming tolerant and dependent on the pain relief drugs given to them while in intensive care.  Opioids, such as Morphine, Fentanyl and Tramadol, are often used for pain relief in newborn babies. However, tolerance and dependence to these drugs builds quickly. Professor Kanwaljeet J. S. (“Sunny”) Anand, Specialty Chief Editor for Frontiers in Pediatrics, aims to tackle this by finding new ways to prevent tolerance development and treat withdrawal syndrome in infants. “High tolerance and addiction is seen in newly born babies born from mothers with a heroine or methadone addiction, but it is also seen in children who require the drugs because they are critically ill,” explained Anand. “They may be on a breathing machine or undergoing frequent procedures that are painful and stressful, so they are given the opiates to take away the pain.” Infantile pain relief is a largely unexplored field, owing to the fact that medical practitioners denied the existence of pain in newborn babies until late in the last century. This meant that even in the early 1980s, neonatal surgery was conducted with little to no pain relief. However, a wealth of […]

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Health

06 May 2016

New treatment for children with ARDS

By Alice Rolandini Jensen, Frontiers science writer Acute Respiratory Distress Syndrome (ARDS) affects hundreds of thousands of people each year, many of them children. Those with this life threatening condition have severely injured and wet lungs, and are treated with mechanical ventilation. Now, a study led by Professor Kanwaljeet Anand published in Frontiers in Pediatrics, investigates the effects of a new steroid treatment on children suffering from ARDS. “Over the last 20-30 years researchers have come up with novel therapies but have not been able to move the needle substantially in terms of reducing mortality of ARDS patients,” explains Professor Anand of Stanford University, USA. “In this work, we conducted the first-ever randomized control trial and saw clinical differences in children treated with steroids.” ARDS is a catch-all term associated with the inability of lung tissue to take up oxygen, the lungs become very stiff and are incapable of transferring oxygen into the blood. ARDS can occur following direct injury of the lungs, such as pneumonia, bronchiolitis, following inhalation of toxic gas and near drowning. It can also develop in patients with severe systemic illnesses. Understanding why ARDS occurs and the differences between mechanisms is key to being able to […]