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ORIGINAL RESEARCH article

Front. Sustain. Food Syst.
Sec. Crop Biology and Sustainability
Volume 8 - 2024 | doi: 10.3389/fsufs.2024.1487446
This article is part of the Research Topic Agricultural Metabolomics for Sustainable Production in the Climate Change Era View all 3 articles

Metabolite Profiling of Some Organs and The Potential of Mukia javanica as An Antihypertension

Provisionally accepted
Mentari Putri Pratami Mentari Putri Pratami 1Wawan Sujarwo Wawan Sujarwo 1Miftahul Huda Fendiyanto Miftahul Huda Fendiyanto 2Ratna Yuniati Ratna Yuniati 3Ifan Rizky Kurniyanto Ifan Rizky Kurniyanto 4Nuniek Widiayani Nuniek Widiayani 5Dr. Mahmoud F. Seleiman Dr. Mahmoud F. Seleiman 6Nawab Ali Nawab Ali 7Muhammad Fuad Anshori Muhammad Fuad Anshori 5*
  • 1 National Research and Innovation Agency (BRIN), Bogor, Jakarta, Indonesia
  • 2 Department of Biology, Faculty of Military Mathematics and Natural Sciences, The Republic of Indonesia Defense University., Bogor, Indonesia
  • 3 University of Indonesia, Depok, West Java, Indonesia
  • 4 Trunojoyo University, Bangkalan, East Java, Indonesia
  • 5 Hasanuddin University, Makassar, Indonesia
  • 6 King Saud University, Riyadh, Riyadh, Saudi Arabia
  • 7 Michigan State University, East Lansing, Michigan, United States

The final, formatted version of the article will be published soon.

    Mukia javanica is a close relative of the cucumber (Cucumis sativus) used to treat hypertension in the Leuwiliang community. Cucumis sativus contains calcium, magnesium, potassium, and phosphorus, which help lower blood pressure. In contrast, the content of metabolite compounds that are useful for lowering blood pressure in M. javanica has not been previously reported. Therefore, this research aimed to identify and determine the secondary metabolite content contained in several M. javanica organs and determine potential compounds that function in treating hypertension. The method used is the gas chromatography-mass spectrometry (GCMS) method. The samples analyzed included several organs of M. javanica, such as roots, stems, leaves, and fruit. Several organs are tested to determine the part of the plant with the most potential secondary metabolite compound content. Data analysis used the R version 3.5.2 program and the Metaboanalyst program. Based on the test results, 98 secondary metabolite compounds were identified and divided into several compound classes, and the most significant number of compounds identified was the terpenoid compound group. The 13-Tetradecen-1-acetate (root), Oleic acid (fruit), Phytol (stem), and 4-hydroxy-3-nitrocoumarin (root) content in Mukia javanica has the potential to be antihypertensive. Based on correlation analysis, the metabolites Hexadecanoic Acid Methyl Ester, Squalene, Vitamin E, and Stigmasta-7,16-Dien-3 show high correlation values. The compound Hexadecanoic Acid Methyl Ester is found in all parts, and it is reported to be associated with antihypertension and antioxidants. In the future, this compound has the potential to be used as a raw material for antihypertensive drugs

    Keywords: Antihypertensive, antioxidant, Correlation analysis, GCMS, Mukia javanica

    Received: 28 Aug 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 Pratami, Sujarwo, Fendiyanto, Yuniati, Kurniyanto, Widiayani, Seleiman, Ali and Anshori. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Muhammad Fuad Anshori, Hasanuddin University, Makassar, Indonesia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.