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ORIGINAL RESEARCH article

Front. Psychol.
Sec. Neuropsychology
Volume 15 - 2024 | doi: 10.3389/fpsyg.2024.1451843

Clinical validity of IntelliSpace Cognition digital assessment platform in Mild Cognitive Impairment

Provisionally accepted
Willem Huijbers Willem Huijbers 1*Nandor K Pinter Nandor K Pinter 2,3*Mandy Spaltman Mandy Spaltman 1Mike Cornelis Mike Cornelis 4Ben Schmand Ben Schmand 5Baraa Alnaji Baraa Alnaji 2Maxwell Yargeau Maxwell Yargeau 2Sarah Harlock Sarah Harlock 2Ryu Platinum Dorn Ryu Platinum Dorn 2Bela Ajtai Bela Ajtai 2Erica S Westphal Erica S Westphal 2Gijs Van Elswijk Gijs Van Elswijk 1
  • 1 Philips Research (Netherlands), Eindhoven, Netherlands
  • 2 Dent Neurosciences Research Center, Dent Neurologic Institute, Buffalo, Illinois, United States
  • 3 University at Buffalo, Buffalo, United States
  • 4 Philips (Netherlands), Amsterdam, Netherlands
  • 5 University of Amsterdam, Amsterdam, Netherlands

The final, formatted version of the article will be published soon.

    We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in a case-control study of patients diagnosed with mild cognitive impairment (MCI) and cognitively normal (CN) older adults. Performance on individual neuropsychological tests, cognitive z-scores, and Alzheimer's disease (AD)-specific composite scores was compared between the CN and MCI groups. These groups were matched for age, sex, and education. Performance on all but two neuropsychological tests was worse in the MCI group. After ranking the cognitive scores by effect size, we found that the memory score was the most impaired, followed by executive functioning. The Early AD/MCI Alzheimer's Cognitive Composite (EMACC) and Preclinical Alzheimer's Cognitive Composite (PACC) scores were constructed from the digital tests on Philips IntelliSpace Cognition. Both AD-specific composite scores showed greater sensitivity and specificity than the Mini-Mental State Examination or individual cognitive z-scores. Together, these results demonstrate the diagnostic value of Philips IntelliSpace Cognition in patients with MCI.

    Keywords: Digital Health, Alzheimer's disease, Neuropsychology, Factor scores, Cognitive composites

    Received: 19 Jun 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Huijbers, Pinter, Spaltman, Cornelis, Schmand, Alnaji, Yargeau, Harlock, Dorn, Ajtai, Westphal and Van Elswijk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Willem Huijbers, Philips Research (Netherlands), Eindhoven, 5656, Netherlands
    Nandor K Pinter, Dent Neurosciences Research Center, Dent Neurologic Institute, Buffalo, Illinois, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.