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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1509287
Dietary Phosphorus Intake Modifies the Association Between Total Cholesterol and Lumbar Spine Bone Mineral Density: Results From NHANES 2011-2016
Provisionally accepted- 1 Department of Orthopedics, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China
- 2 Department of Cardiology, Air Force Medical University Tangdu Hospital, Xi'an, Shaanxi, China
Background: The connection between total cholesterol (TC) and lumbar spine bone mineral density (BMD) is well-documented, yet the role of dietary phosphorus intake in this relationship is not fully understood. This cross-sectional study aims to explore how dietary phosphorus affects the link between TC and lumbar spine BMD.Methods: Data from the National Health and Nutrition Examination Survey (NHANES) spanning 2011 to 2016 were analyzed, involving 7,155 participants. Based on the median daily phosphorus intake, participants were divided into a low phosphorus intake group (phosphorus intake < 1445 mg/d) and a high phosphorus intake group (phosphorus intake >= 1445 mg/d). A multiple linear regression analysis was performed to investigate the association between TC and lumbar spine BMD, with a focus on determining if dietary phosphorus intake may serve as a potential influencing factor.Results: The study revealed a negative association between TC and lumbar spine BMD. The strength of this relationship varied between the low and high phosphorus intake groups, with β values of -0.219 (95% CI: -0.334 to -0.105) for the low group and -0.420 (95% CI: -0.548 to -0.291) for the high group. Additionally, there was an interaction between total cholesterol and dietary phosphorus intake in reducing lumbar spine bone density (P for interaction = 0.0168).Our study results indicate that dietary phosphorus intake influences the relationship between TC and lumbar spine BMD, which may have important implications for clinical management.
Keywords: Dietary phosphorus intake, Total cholesterol, LUMBAR SPINE BONE MINERAL DENSITY, Interaction, Cross-sectional study
Received: 10 Oct 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Yu, Li, Su, Cao, Yu, Ye and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mo Li, Department of Orthopedics, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China
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