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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1492621
This article is part of the Research Topic Community Series in : The Role of Vitamin D as an Immunomodulator - Volume II View all 4 articles

A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults

Provisionally accepted
Zi-yue Liu Zi-yue Liu Zi-yue Liu Zi-yue Liu Sha Liu Sha Liu Chunyang Wang Chunyang Wang Yanming Bi Yanming Bi Jinxiu Wang Jinxiu Wang Yang Li Yang Li Tala Shi Tala Shi Mi Wei Mi Wei Caiyun Chen Caiyun Chen Zhiyong Hu Zhiyong Hu *
  • Binzhou Medical University, Binzhou, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to investigate the potential association between serum 25(OH)D levels and the risk of hyperlipidemia in adults through a prospective cohort study conducted in Zhejiang Province. Methods: Baseline surveys and follow-up studies were conducted to collect and analyze follow-up data over a three-year period. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL, insufficiency as 20-29 ng/mL, and sufficiency as 25(OH)D ≥ 30 ng/mL. Hyperlipidemia or dyslipidemia was defined as the presence of hypercholesterolemia, hypertriglyceridemia, or both. The relationship between demographic characteristics and the incidence of hyperlipidemia among the study participants was explored. Results: A total of 1,210 participants were included in this study, with 43.80% being male. The mean age of the participants was 51.84 ± 14.37 years, and the average serum 25(OH)D level was 25.89 (21.50, 29.82) ng/mL. A significant difference in the proportion of vitamin D deficiency was observed between males and females (22.06% vs 10.94%, P < 0.001). Vitamin D deficiency and insufficiency were prevalent among the middle-aged and elderly population (78.24%). Significant differences were found between the two groups in multiple sociodemographic variables, behavioral factors, and metabolic risk factors (P < 0.05). The incidence of hyperlipidemia among vitamin D-deficient individuals was 1.612 times higher than that among vitamin D-sufficient individuals (95% confidence interval [CI]: 1.228-2.116; P < 0.001). After fully adjusting for confounding factors, the multivariate-adjusted hazard ratio (HR) was 1.572 (95% CI: 1.187-2.08; P = 0.002), indicating a difference in the incidence of hyperlipidemia across different serum vitamin D levels.This cohort study reveals a significant association between serum 25(OH)D levels and the incidence of hyperlipidemia. Additionally, lifestyle factors associated with vitamin D deficiency are also correlated with the incidence of hyperlipidemia. These findings provide further evidence for improving blood lipid profiles through adjustments in vitamin D intake or related lifestyle modifications.

    Keywords: Vitamin D1, Hyperlipidaemia2, cohort study3, 25(OH)D4, adults5 Manuscript length

    Received: 07 Sep 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Zi-yue Liu, Liu, Wang, Bi, Wang, Li, Shi, Wei, Chen and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhiyong Hu, Binzhou Medical University, Binzhou, 256603, Shandong Province, China

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