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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1489359

Lactiplantibacillus plantarum HM-P2 influences gestational gut microbiome and microbial metabolism

Provisionally accepted
Bin Liu Bin Liu Zhenzhen Zhang Zhenzhen Zhang Junying Zhao Junying Zhao Xianping Li Xianping Li Yaru Wang Yaru Wang Lu Liu Lu Liu Weicang Qiao Weicang Qiao Lijun Chen Lijun Chen *
  • National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co., Ltd., Beijing, China

The final, formatted version of the article will be published soon.

    Human milk-derived probiotics are beneficial bacteria that provide gestational health benefits, for both pregnant women and their offspring. The study aims to investigate whether the administration of human milk-derived probiotic L. plantarum HM-P2 could effectively influence gestational health. The gestational humanized microbiome model was built by fecal microbiome transplant from gestational women into germ-free (GF) mice. HM-P2 was successfully planted and increased the top crypt depth of the colon, and microbes such as L. reuteri, Anaerofilum sp. An201, and Gemmiger were up-regulated in the HM-P2 group throughout gestation. HM-P2 significantly promoted the contents of intestinal caproic acid, bile acids, and tryptophan catabolites such as serotonin. Gut microbes were associated with these bile acids and tryptophans. HM-P2 could modulate the microbial community and microbial metabolites in gestational humanized GF mice. This probiotic strain could be a potential gestational dietary supplement with health benefits.

    Keywords: Probiotics, Lactiplantibacillus plantarum HM-P2, Humanized germ-free mice, Fecal microbiome transplantation, Microbial Metabolites

    Received: 01 Sep 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Liu, Zhang, Zhao, Li, Wang, Liu, Qiao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lijun Chen, National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co., Ltd., Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.