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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1477537
This article is part of the Research Topic Metabolic Disorders and Fibrosis: the Mechanism and Potential Target View all 4 articles

Education and metabolic syndrome: a Mendelian randomization study

Provisionally accepted
Dong Liu Dong Liu 1Zi-xiang Xu Zi-xiang Xu 2*Xu-lian Liu Xu-lian Liu 3*Hai-ling Yang Hai-ling Yang 1*Lingling Wang Lingling Wang 4*Yan Li Yan Li 3*
  • 1 china Japan union hospital of jilin university, Changchun, China
  • 2 Jilin Cancer Hospital, Changchun, Jilin Province, China
  • 3 First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
  • 4 Stroke Unit, the Affiliated Hospital of Beihua University, Changchun, Jilin, China

The final, formatted version of the article will be published soon.

    The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.Method: single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse varianceweighted (IVW) method utilized for analysis.Results: Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48-0.63, P = 2.18E-51), waist circumference (OR = 0.80, 95% CI = 0.76-0.83, P = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95-0.97; P = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91-0.97, P = 7.58E-6) and triglycerides (OR = 0.83, 95% CI := 0.79-0.87, P = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18-1.25, P = 1.45E-31). Early intervention strategies are crucial for individuals with lower levels of education in effectively managing MetS and its related components.The findings of this study suggest that education can decrease the incidence of MetS. It is crucial to emphasize early intervention and diagnosis in individuals with lower levels of education.

    Keywords: Education, metabolic syndrome, Waist Circumference, Hypertension, Fasting blood glucose, Triglycerides, High-density lipoprotein cholesterol

    Received: 08 Aug 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Liu, Xu, Liu, Yang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zi-xiang Xu, Jilin Cancer Hospital, Changchun, Jilin Province, China
    Xu-lian Liu, First Affiliated Hospital of Jilin University, Changchun, 130012, Jilin Province, China
    Hai-ling Yang, china Japan union hospital of jilin university, Changchun, China
    Lingling Wang, Stroke Unit, the Affiliated Hospital of Beihua University, Changchun, 132011, Jilin, China
    Yan Li, First Affiliated Hospital of Jilin University, Changchun, 130012, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.