AUTHOR=Liu Dong , Xu Zi-Xiang , Liu Xue-lian , Yang Hai-Ling , Wang Ling-ling , Li Yan 

TITLE=Education and metabolic syndrome: a Mendelian randomization study

JOURNAL=Frontiers in Nutrition

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1477537

DOI=10.3389/fnut.2024.1477537

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Aims</title><p>The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.</p></sec><sec id="sec2"><title>Method</title><p>Single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.</p></sec><sec id="sec3"><title>Results</title><p>Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48–0.63, <italic>p</italic> = 2.18E−51), waist circumference(OR = 0.80, 95% CI = 0.76–0.83, <italic>p</italic> = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95–0.97; <italic>p</italic> = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91–0.97, <italic>p</italic> = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79–0.87, <italic>p</italic> = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18–1.25, <italic>p</italic> = 1.45E-31).</p></sec><sec id="sec4"><title>Conclusion</title><p>The findings of this study suggest that education can decrease the incidence of MetS.</p></sec>