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BRIEF RESEARCH REPORT article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1372393
This article is part of the Research Topic Precision Nutrition and Nutrients: Making the Promise a Reality View all 5 articles

Association between two common SNPs, rs6564851 and rs6420424, and lutein and zeaxanthin levels in a cohort of U.S. postmenopausal women with a family history of breast cancer

Provisionally accepted
Ann Von Holle Ann Von Holle 1Min Shi Min Shi 1Katie M. O'Brien Katie M. O'Brien 1Clarice Weinberg Clarice Weinberg 1Dale Sandler Dale Sandler 1Yong-Moon ("Mark") Park Yong-Moon ("Mark") Park 2,3*
  • 1 National Institute of Environmental Health Sciences (NIH), Durham, United States
  • 2 University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
  • 3 Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

The final, formatted version of the article will be published soon.

    A better understanding of the factors contributing to systemic concentrations of carotenoids is necessary given the weak correlations between circulating levels and dietary intake of carotenoids. Although genetic variation may play a key role in the interindividual variability in carotenoid concentrations, few genome-wide association studies (GWAS) have focused on carotenoids.We used a random sample (n=519) of postmenopausal participants in the Sister Study with data on genotypes and plasma carotenoid levels to conduct GWAS for each of five carotenoids (mcg/mL): alpha-carotene, beta-carotene, cryptoxanthin, lycopene, and lutein/zeaxanthin. We used linear regression models and an additive genetic model to evaluate associations between 530,000 variants and inverse normal transformed carotenoid concentrations.We found evidence for one genome-wide statistically significant association with the combined carotenoids of lutein and zeaxanthin for the rs6564851-C (beta=-0.377, se=0.059, p=4.6x10 -10 ) and rs6420424-A (beta = -0.334, se=0.059, p=2.2X10 -8 , upstream of the beta-carotene oxygenase 1 (BCO1) gene on chromosome 16. No other variant was associated with any of the remaining four carotenoids.Our results for the common rs6564851 and rs6420424 variants correspond to previous findings. Although biologic mechanisms explain the association between beta-carotene and this variant, the inverse association with lutein/zeaxanthin will require further investigation.

    Keywords: Carotenoids, Lutein, Zeaxanthins, Genome-Wide Association Study, Genotype, BCO1 carotenoids, zeaxanthin, genome-wide association studies

    Received: 21 Feb 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Von Holle, Shi, O'Brien, Weinberg, Sandler and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yong-Moon ("Mark") Park, University of Arkansas for Medical Sciences, Little Rock, 72205, Arkansas, United States

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