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BRIEF RESEARCH REPORT article

Front. Neuroanat.
Volume 18 - 2024 | doi: 10.3389/fnana.2024.1480971
This article is part of the Research Topic Updates and Discussions About Basal Ganglia and Their Circuits View all 5 articles

New resubmission explanation

Provisionally accepted
Leila M. Guissoni Campos Leila M. Guissoni Campos 1*Gyovanna S. Campanari Gyovanna S. Campanari 1Jeferson Santiago Jeferson Santiago 2Eduardo V. Santos Eduardo V. Santos 1Alana C. Santos Alana C. Santos 1Mayara L. Cabrini Mayara L. Cabrini 1Mauro Audi Mauro Audi 1Lívia C. Motta-Teixeira Lívia C. Motta-Teixeira 3Stephannie M. Bodra Stephannie M. Bodra 3Maressa M. Gualassi Maressa M. Gualassi 3Isabela B. Costa Isabela B. Costa 1Viviane C. Araujo Viviane C. Araujo 1Luciana Pinato Luciana Pinato 2
  • 1 Universidade de Marília, Marilia, Brazil
  • 2 Marília, São Paulo State University, São Paulo, São Paulo, Brazil
  • 3 Santa Casa of Sao Paulo, São Paulo, São Paulo, Brazil

The final, formatted version of the article will be published soon.

    This brief study employs anatomical and neurochemical approaches to investigate the presence of circadian rhythm-related genes in motor areas associated with basal ganglia circuits. In the initial version of the manuscript, the results demonstrated the presence of clock gene proteins in the substantia nigra during both daytime and nighttime periods. Following a reviewer's suggestion, we expanded our investigation in this primate study to include the examination of the clock proteins Per1, Per2, and Cry1 in a new brain area within the basal ganglia circuitry, the subthalamic nucleus (STN). Therefore, we opted to focus on characterizing the presence of these proteins and submitted this revised version to a journal with an anatomical focus.The significance of the STN lies in its connections with motor and non-motor regions, including the cerebral cortex, thalamus, globus pallidus, substantia nigra, striatum, and brainstem. Together, the substantia nigra and subthalamic nucleus are key midbrain structures involved in movement disorders, particularly those associated with Parkinsonism. The aim of this study is to demonstrate the presence of these proteins in the motor areas of the primate Sapajus apella. Studies conducted in diurnal species, especially primates, are crucial for understanding evolutionary questions regarding the circadian system and rhythmic activity in motor areas.Thank you for your consideration. I look forward to hearing from you.

    Keywords: Substantia Nigra, subthalamic nucleus and clock proteins cryptochrome, Clock genes, Dopamine, nocturnal/diurnal behavior

    Received: 14 Aug 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 Guissoni Campos, Campanari, Santiago, Santos, Santos, Cabrini, Audi, Motta-Teixeira, Bodra, Gualassi, Costa, Araujo and Pinato. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Leila M. Guissoni Campos, Universidade de Marília, Marilia, Brazil

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