AUTHOR=Guissoni Campos Leila Maria , Campanari Gyovanna Sorrentino dos Santos , Santiago Jeferson , Santos Eduardo Vinicius Barboza , Santos Alana Cristy Ghiraldelli , Cabrini Mayara Longui , Audi Mauro , Costa Isabela Bazzo , Evangelista de Araujo Viviane Canhizares , Bodra Stephannie Monaco , Gualassi Maressa Monteiro Pereira , Motta-Teixeira Lívia Clemente , Pinato Luciana TITLE=Characterization of clock proteins in the substantia nigra and subthalamic nucleus of the Sapajus apella primate JOURNAL=Frontiers in Neuroanatomy VOLUME=18 YEAR=2024 URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2024.1480971 DOI=10.3389/fnana.2024.1480971 ISSN=1662-5129 ABSTRACT=

Clock genes, which are essential for suprachiasmatic nucleus (SCN) function, also play critical roles in other brain regions, and their expression have been the subject of various studies. An increasingly deeper understanding of the expression of these genes in different species contributes to our knowledge of their functions and the factors influencing their expression. Considering that most studies have been conducted in nocturnal rodents, in this study we investigated the presence of Per1, Per2 and Cry1 in neurons of the substantia nigra (SN) and subthalamic nucleus (STN) in a diurnal primate. The immunoreactivity of Per1, Per2, and Cry1 was analyzed using immunohistochemistry, revealing significant Per1-IR, Per2-IR, and Cry1-IR in the SN. While Per1-IR and Per2-IR were also observed in the STN, no Cry1-IR staining was detected in the STN. These results confirm the presence of proteins that regulate circadian rhythms in areas associated with motor behavior.