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CASE REPORT article

Front. Lupus
Sec. Disease Mechanisms in Lupus
Volume 2 - 2024 | doi: 10.3389/flupu.2024.1484352

Crosstalk between Systemic Lupus Erythematosus and Sickle Cell Syndromes-a report of two cases

Provisionally accepted
Dhriti Sundar Das Dhriti Sundar Das *
  • All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

The final, formatted version of the article will be published soon.

    Autoimmune disease and sickle cell abnormalities are reported have some common pathogenic pathways. We describe two cases of sickle cell trait (SCT) presented with antibodies to antinuclear antigens and clinical features compatible with systemic lupus erythematosus (SLE). These patients were from eastern state of India i.e. Odisha. Both patients have documented sickle cell trait and positive for anti-double stranded DNA antibodies. Both patients presented with lupus nephritis without any obvious features of sickle cell hemoglobinopathies. Crosstalk between SLE and SCT may explain such association which needs validation in future large-scale studies.

    Keywords: Sickle Cell Trait, systemic lupus erythematosus, autoimmune disease, Lupus Nephritis, crosstalk

    Received: 21 Aug 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Das. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dhriti Sundar Das, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, India

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