AUTHOR=Das Dhriti Sundar 

TITLE=Case Report: Crosstalk between systemic lupus erythematosus and sickle cell syndromes—two cases from eastern India

JOURNAL=Frontiers in Lupus

VOLUME=Volume 2 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/lupus/articles/10.3389/flupu.2024.1484352

DOI=10.3389/flupu.2024.1484352

ISSN=2813-6934

ABSTRACT=Autoimmune disease and sickle cell abnormalities are reported have some common pathogenic pathways. We describe two cases of sickle cell trait (SCT) presented with antibodies to antinuclear antigens and clinical features compatible with systemic lupus erythematosus (SLE). These patients were from eastern state of India i.e. Odisha. Both patients have documented sickle cell trait and positive for anti-double stranded DNA antibodies. Both patients presented with lupus nephritis without any obvious features of sickle cell hemoglobinopathies. Crosstalk between SLE and SCT may explain such association which needs validation in future large-scale studies.