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REVIEW article

Front. Allergy
Sec. Food Allergy
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1505834
This article is part of the Research Topic Gut Microbiota Changes: A Key Driver of Increased Food Allergy Prevalence View all 4 articles

INTESTINAL PERMEABILITY, FOOD ANTIGENS AND THE MICROBIOME: A MULTIFACETED PERSPECTIVE

Provisionally accepted
Francesco Valitutti Francesco Valitutti 1*Maurizio Mennini Maurizio Mennini 2Gianluca Monacelli Gianluca Monacelli 1Giulia Fagiolari Giulia Fagiolari 1Marisa Piccirillo Marisa Piccirillo 2Giovanni Di Nardo Giovanni Di Nardo 2Giuseppe Di Cara Giuseppe Di Cara 1
  • 1 Department of Medicine, University of Perugia, Perugia, Italy
  • 2 Department of Neurosciences, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Lazio, Italy

The final, formatted version of the article will be published soon.

    The gut barrier encompasses several interactive, physical, and functional components, such as the gut microbiota, the mucus layer, the epithelial layer and the gut mucosal immunity. All these contribute to homeostasis in a well-regulated manner.Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure to antibiotics, thus diminishing protective immunity and leading to the onset of chronic diseases. Several gaps of knowledge still exist as regards this multi-level interaction. In this review we aim to summarize current evidence linking food antigens, microbiota and gut permeability interference in diverse disease conditions such as celiac disease (CeD), non-celiac wheat sensitivity (NCWS), food allergies (FA), eosinophilic gastrointestinal disorder (EOGID) and irritable bowel syndrome (IBS). Specific food elimination diets are recommended for CeD, NCWS, FA and in some cases for EOGID. Undoubtfully, each of these conditions is very different and quite unique, albeit food antigens/compounds, intestinal permeability and specific microbiota signatures orchestrate immune response and decide clinical outcomes for all of them. Table 3: pathways of crosstalk between brain and gut-

    Keywords: intestinal permeability, Gut barrier, Celiac Disease, food allergy, Eosinophilic gastrointestinal disorders, Irritable Bowel Syndrome

    Received: 03 Oct 2024; Accepted: 16 Dec 2024.

    Copyright: © 2024 Valitutti, Mennini, Monacelli, Fagiolari, Piccirillo, Di Nardo and Di Cara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Francesco Valitutti, Department of Medicine, University of Perugia, Perugia, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.