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CORRECTION article

Front. Nutr., 27 February 2024
Sec. Clinical Nutrition
Volume 11 - 2024 | https://doi.org/10.3389/fnut.2024.1376599

Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study

This article is a correction to:

  1. Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study

    1. Read original article
\r\nErin D. Lewis&#x;Erin D. Lewis1†Edwin F. OrtegaEdwin F. Ortega1Maria Carlota DaoMaria Carlota Dao1Kathryn BargerKathryn Barger1Joel B. MasonJoel B. Mason1John M. LeongJohn M. Leong2Marcia S. OsburneMarcia S. Osburne2Loranne MagounLoranne Magoun2Felix J. Nepveux VFelix J. Nepveux V2Athar H. ChishtiAthar H. Chishti3Christopher SchwakeChristopher Schwake3Anh QuynhAnh Quynh3Cheryl H. GilhoolyCheryl H. Gilhooly1Gayle PettyGayle Petty1Weimin Guo&#x;Weimin Guo1†Gregory MatuszekGregory Matuszek1Dora Pereira&#x;Dora Pereira4†Manju ReddyManju Reddy5Jifan WangJifan Wang1Dayong WuDayong Wu1Simin N. Meydani Simin N. Meydani1*Gerald F. Combs Jr.Gerald F. Combs Jr.1
  • 1Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States
  • 2Department of Molecular Biology and Microbiology, Tufts University, Boston, MA, United States
  • 3Department of Developmental, Molecular and Chemical Biology, Tufts University, Boston, MA, United States
  • 4Department of Pathology, University of Cambridge, Cambridge, United Kingdom
  • 5Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States

A corrigendum on
Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study

by Lewis, E. D., Ortega, E. F., Dao, M. C., Barger, K., Mason, J. B., Leong, J. M., Osburne, M. S., Magoun, L., Nepveux, V. F. J., Chishti, A. H., Schwake, C., Quynh, A., Gilhooly, C. H., Petty, G., Guo, W., Matuszek, G., Pereira, D., Reddy, M., Wang, J., Wu, D., Meydani, S. N., and Combs, G. F. (2023). Front. Nutr. 10:1230061. doi: 10.3389/fnut.2023.1230061

In the published article, there was an error. The error involved an inconsistency between our abstract and discussion regarding the observed effects of one treatment on some secondary outcomes, GI symptoms.

A correction has been made to Abstract, subsection Results.

This section previously stated:

“Supplementation with any form of iron did not affect any primary endpoint. In Phase I, the frequency of gastrointestinal symptoms associated with FS was unaffected by dosing with MNP or weekly administration; but participants taking IHAT more frequently reported abdominal pain (27%, p < 0.008) and nausea (4%, p = 0.009) than those taking FS, while those taking ASP more frequently reported nausea (8%, p = 0.009). Surprisingly, only 9% of participants taking IHAT at 120 mg Fe/day (Phase II) reported abdominal pain and no other group reported that symptom.”

The corrected section appears below:

“Supplementation with any form of iron did not affect any primary endpoint. Regarding secondary endpoints, in Phase I participants taking IHAT more frequently reported abdominal pain (27%, p = 0.008) than other iron forms; those taking the weekly FS dose more frequently reported nausea (20%, P = 0.009) than the other forms and modes of administration. In phase II, no such differences were observed.”

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: iron, ferrous sulfate, malarial infectivity, bacterial proliferation, gut inflammation, IHAT, fungal iron

Citation: Lewis ED, Ortega EF, Dao MC, Barger K, Mason JB, Leong JM, Osburne MS, Magoun L, Nepveux V FJ, Chishti AH, Schwake C, Quynh A, Gilhooly CH, Petty G, Guo W, Matuszek G, Pereira D, Reddy M, Wang J, Wu D, Meydani SN and Combs GF Jr (2024) Corrigendum: Safe and effective delivery of supplemental iron to healthy adults: a two-phase, randomized, double-blind trial – the safe iron study. Front. Nutr. 11:1376599. doi: 10.3389/fnut.2024.1376599

Received: 25 January 2024; Accepted: 12 February 2024;
Published: 27 February 2024.

Edited and reviewed by: Johannes le Coutre, University of New South Wales, Australia

Copyright © 2024 Lewis, Ortega, Dao, Barger, Mason, Leong, Osburne, Magoun, Nepveux V, Chishti, Schwake, Quynh, Gilhooly, Petty, Guo, Matuszek, Pereira, Reddy, Wang, Wu, Meydani and Combs. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Simin N. Meydani, simin.meydani@tufts.edu

†Present addresses: Erin D. Lewis, KGK Science, Inc., London, Ontario, ON, Canada
Weimin Guo, Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States
Dora Pereira, Vifor Pharma UK Ltd., Cambridge, England, United Kingdom

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.