About this Research Topic

Background

Strategies for identifying molecular profiling can help select treatments and improve the patient management through the identification of biomarkers of different diseases that can classify the patients into different biological subgroups. Proteomics and peptidomics are considered as promised tools for improved clinical assessment as they allow the identification of specific proteins of various diseases and endogenous peptides, respectively. The specific strategies in addition to prognosis, early diagnosis and treatment response, also promote the discovery of more effective therapies through the understanding of the pathology of disease and the identification of novel therapeutic targets.

In recent years, the application of peptidomics and proteomics has successfully expanded to other research areas such as food and nutrition. As it is known, a large number of peptides are present in food products or generated during the storage, digestion, or food processing.

Like proteomics and peptidomics, metabolomics is considered as one of the most relevant methods, both for evaluating the metabolomic pathway in the clinical field and to assess the metabolites in food digestion samples as well as to study the changes in metabolome after dietary interventions.

The rapid development of metabolomics, peptidomics and proteomics is due to the advancement in high-resolution of mass spectrometry, which provides a more detailed metabolites and peptides profiling in clinical and food samples.

This Research topic aims to gather articles focused on the development and application of proteomics, peptidomics and metabolomics in the clinical field and in food science, for evaluating and understanding of the proteins /peptides/metabolites in clinical samples and in food digestion and their impact on the human health.

This Research Topic describes the new trends of peptidomics, proteomics and metabolomics in a clinical context such as the discovery of a disease biomarker, drug development and identification of novel therapeutic targets and in food research such as identification of bioactive peptides and biomarkers on food digestion.

The Research Topic “Application of Metabolomics, Peptidomics and Proteomics in Human Nutrition and Health” welcomes high-quality research works that focus on the new ideas regarding the development and application of proteomics, peptidomics and metabolomics in the clinical field and in food science, for evaluation and understanding of the proteins /peptides/metabolites in clinical samples and in food digestion samples and their impact on the human health.

We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:

• Application of peptidomics and metabolomics techniques in food digestion samples (understanding food protein digestion, microbial contribution to food protein hydrolysis, identification of food-derived bioactive peptides and peptide biomarkers, metabolites during the metabolome and the pathway motifs of the different biological systems (tissue, organisms, cells etc).

• Proteomics/peptidomics/metabolomics methods for identification of peptides and metabolites in biological fluids

• Proteomics/peptidomics for the identification of novel therapeutic targets.

• Development of optimized peptidomic strategies for analysis of biomarkers

• Development of analytical protocol for quantification of peptides and metabolites in food digestion samples

• Development of analytical protocol for quantification of peptides/metabolites in clinical samples

• Proteomics: Pharmaceutical application and search in molecular diseases

Keywords: Proteomics, Peptidomics, Mass spectrometry, Bioinformatics, peptide quantification, metabolomics, human health, analytical techniques, drug discovery, Pharmaceutical application, Metabolomic pathway, Food digestion

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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