About this Research Topic
Liver is the site of complex immune activity mediated by a variety immune cell repertoire and non-hematopoietic cell populations. Therefore, liver has also been considered as an immune organ. Abnormal development and differentiation of immune cells are directly involved in the onset and progression in liver diseases. Hematopoiesis in the bone marrow and T lymphocyte maturation in the thymus constitute the major events of immune cell development. In addition, immune cells have strong plasticity; different tissue microenvironment further promotes the differentiation of macrophages and T helper cells into specific phenotypes and functional subsets. With the development of single-cell sequencing and multicolor flow cytometry technologies, new immune cell subsets are continuously identified, refreshing the understanding of the regulatory mechanisms of immune cell differentiation and disease pathogenesis.
This research topic aims to present the current state of understanding of immune cell development and differentiation in liver diseases, including the interaction between the immune cells and the microenvironment, the regulatory mechanisms of the abnormally differentiated immune cells in the occurrence of diseases, and to explore potential therapeutic strategies.
We welcome Original Research, Methods, Review and Mini-Review articles that cover, but are not limited to the following subtopics:
• Regulation mechanism of immune cell development and differentiation
• Immune cell heterogeneity and the discovery of new subpopulations
• Immune cell development and differentiation in liver diseases
• Local microenvironment and immune cell differentiation
This research topic aims to present the current state of understanding of immune cell development and differentiation in liver diseases, including the interaction between the immune cells and the microenvironment, the regulatory mechanisms of the abnormally differentiated immune cells in the occurrence of diseases, and to explore potential therapeutic strategies.
We welcome Original Research, Methods, Review and Mini-Review articles that cover, but are not limited to the following subtopics:
• Regulation mechanism of immune cell development and differentiation
• Immune cell heterogeneity and the discovery of new subpopulations
• Immune cell development and differentiation in liver diseases
• Local microenvironment and immune cell differentiation
Keywords: Innate immunity, adaptive immunity, microenvirement, pathogenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
