About this Research Topic

Background

Oxidative stress is a phenomenon generated when the balance between reactive oxygen species and antioxidants as well as antioxidant enzymes existing endogenously in the body are destroyed, and cause oxidative damage to DNA, proteins, lipid, etc. If not strictly controlled, oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body aging process and cause acute pathologies (i.e., trauma and stroke).

High altitude medicinal plants that possess strong healing properties have been used for a long time in different cultures around the world to treat different diseases and disorders. These plants produce several types of unique bioactive compounds due to critical climatic conditions. A large number of potentially bioactive compounds, primarily polyphenols, alkaloids, glycosides, volatile oils, flavonoids, phenolic acids, have been explored from natural sources for their chemo-protective activities. Epidemiological and clinical evidences have shown that these phytochemicals provide considerable health benefits.

The aim of this Research Topic is to attract original research articles and review articles with a focus on high altitude medicinal plants, bioactive compounds, and their potential therapeutic applications to treat different oxidative stress induced diseases and disorders. We encourage submissions such as pre-clinical, clinical studies and reviews describing the interplay between oxidative stress and related diseases and disorders.

• In-vitro and in-vivo pharmacological assessment of phytochemicals / chemically characterised extracts against different diseases via regulation of oxidative stress

• Natural bioactive compound-triggered molecular pathways in oxidative stress-mediated diseases

• Phytochemicals targeted signaling pathways on oxidative stress

• The role of phytochemicals in mitigating oxidative stress

All manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).

Keywords: High altitude, Himalaya, bioactive compounds, health promoting effects, oxidative stress, biological applications

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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