Clinic-oriented Multifunctional Biomaterials: From Rational Design to Applications

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Background

In the clinic, various kinds of diseases that derived not only from exogenous, such as bone fracture, skin wound, and brain injury, but also from endogenous, e.g., tumors, cardiovascular and cerebrovascular pathological changes including stenosis, infarction, and hemorrhage, are all in urgent need of biomaterials to improve their function restoration. Traditionally, clinic-oriented biomaterials focus on their therapy functions for specific diseases. However, most developed ones are non-friendly for clinical use, such as difficulties in handling. Moreover, new therapy modes like minimally invasive surgery are demanding biomaterials with multiple functions to satisfy the clinical requirements. For example, biomedical hydrogels can be prepared by rational design of appropriate components, chemistry, and structure to realize multiple functions such as injectable, self-healing, adhesion, and stimuli-response. Thus, the design and fabrication of multifunctional biomaterials that are capable of better meeting the needs in the clinics are worthy of further exploration by researchers.

Although great success has been achieved in the development of various biomaterials, there are only a few products that can meet the requirements in clinical applications. And thus, this research topic aims to attract the attention of more researchers and spread their latest progress on clinic-oriented multifunctional biomaterials, which are expected to integrate the necessary demands, ranging from disease therapy and management to the handling of the surgical operation. Biomaterials with great potential as diagnosis are also accessible, even though they have just been investigated in in vitro instead of in vivo clinical applications. Original research, short communication, and review article are all welcome to present a comprehensive understanding of the recent advancements.

Topics include but are not limited to:
1. Design, synthesis, and fabrication of novel multifunctional biomaterials for specific clinical diseases.
2. Many forms of multifunctional biomaterials, such as nanoparticles, nanofibers, hydrogels, and scaffolds.
3. Novel engineering approaches for developing clinically relevant biomaterials, such as microfluids, three-dimensional printing, and electrospinning.
4. Biomaterials with various types (such as polymer, metal, and ceramic), sizes (nano, micro, and macro), and dimensions (0D, 1D, 2D, and 3D).
5. Potential application in the clinic and effectiveness evaluation.
6. Interactions between biomaterials and biological systems, and related mechanisms study.

Keywords: Multifunctional biomaterials, Clinical disease, Rational design, Repair, Regeneration

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