Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells and some uncertain biological effects of drugs on cancer cells affect the efficacy of various anticancer drugs. In addition to inducing apoptosis, drugs also exert their anticancer efficacy by triggering other cell death modes, such as autophagy, senescence, mitotic catastrophe, ferroptosis, necroptosis, pyroptosis, paraptosis ,etc. Further, drugs inducing non-apoptotic cell death modes could overcome apoptosis resistance-mediated multidrug resistance, no matter how complex the mechanisms underlying apoptosis resistance of cancer cells are. Some cell death modes also exhibit immunogenicity, which could enhance the anticancer immune effects of the body. It is noteworthy that these cell death modes are usually not presented separately, resulting in the complex interactions (including synergistic, complementary, additive, even competitive or antagonistic effects) among them during cancer treatment. Therefore, in-depth understanding of the molecular mechanisms underlying drug-induced different cell death modes and the interactions among these cell death modes, has a positive significance for the research and development of new anticancer drugs and treatment strategies.
In light of this, the current Research Topic focuses on recent progress made in researching the molecular mechanisms of various cell death modes induced by anticancer drugs. We are specifically interested in the interaction among different cell death modes. The discovery, design and synthesis of anticancer drugs based on various cell death modes are also encouraged. Reviews of the progress of the molecular mechanism in various cell death modes are welcomed for submission.
• Design, synthesis, and evaluation of novel anticancer agents based on non-apoptotic cell death modes.
• The monomer compounds from natural products in the treatment of cancers by inducing non-apoptotic cell death modes.
• Mechanism study of various cell death modes induced by drugs in cancer treatment.
• The interaction among different cell death modes.
Please note this Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.
Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells and some uncertain biological effects of drugs on cancer cells affect the efficacy of various anticancer drugs. In addition to inducing apoptosis, drugs also exert their anticancer efficacy by triggering other cell death modes, such as autophagy, senescence, mitotic catastrophe, ferroptosis, necroptosis, pyroptosis, paraptosis ,etc. Further, drugs inducing non-apoptotic cell death modes could overcome apoptosis resistance-mediated multidrug resistance, no matter how complex the mechanisms underlying apoptosis resistance of cancer cells are. Some cell death modes also exhibit immunogenicity, which could enhance the anticancer immune effects of the body. It is noteworthy that these cell death modes are usually not presented separately, resulting in the complex interactions (including synergistic, complementary, additive, even competitive or antagonistic effects) among them during cancer treatment. Therefore, in-depth understanding of the molecular mechanisms underlying drug-induced different cell death modes and the interactions among these cell death modes, has a positive significance for the research and development of new anticancer drugs and treatment strategies.
In light of this, the current Research Topic focuses on recent progress made in researching the molecular mechanisms of various cell death modes induced by anticancer drugs. We are specifically interested in the interaction among different cell death modes. The discovery, design and synthesis of anticancer drugs based on various cell death modes are also encouraged. Reviews of the progress of the molecular mechanism in various cell death modes are welcomed for submission.
• Design, synthesis, and evaluation of novel anticancer agents based on non-apoptotic cell death modes.
• The monomer compounds from natural products in the treatment of cancers by inducing non-apoptotic cell death modes.
• Mechanism study of various cell death modes induced by drugs in cancer treatment.
• The interaction among different cell death modes.
Please note this Research Topic does not accept publication studies carried out with crude extracts or mixtures. Only the use of highly purified, chemically characterized compounds is acceptable.