Enzyme Immobilization Technologies and Their Biomanufacturing Applications

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Background

Bioprocessing uses enzymes to manufacture products in a diversity of industrial fields, including chemicals industry, pulp and paper, pharmacy, energy, food and feed, detergents, textiles, materials, and polymers. In the past few years, lignin-degrading enzymes have been applied in many industrial processes. However, their low catalytic efficiencies and operational stability limit their practical and multi-purpose applications in different fields of the current industrial processes. It is necessary to focus on the potential industrial applications of enzymes in various fields of the modern industry, and mainly pay attention to the latest trends of green enzyme evolution and immobilized biotechnology.

Enzyme immobilization approaches have been adopted as parallel or mutually auxiliary strategies for improving performance of enzymes. Recent reports show that the enzymatic activity and stability are improved through immobilization. The major issue for obtaining improved biocatalysts application in industrial biotechnology is how to remold enzyme with mild, simple, and effective methods, especially in the actual complex catalytic environment. With the rapid development of chemistry, computers, materials and other disciplines, more and more methods have been used to optimize the design of enzyme modification or immobilization. Enzyme immobilization is growing rapidly and will become a powerful norm in bio-catalysis with much controlled features, such as selectivity, specificity, stability, resistivity, induce activity, reaction efficacy, muti-usability, improved mass transfer efficiency, high catalytic turnover, optimal yield, ease in recovery, and cost-effectiveness. In addition, enzyme modification and immobilization strategies for complex enzyme processes such as multi-enzyme catalysis and non-aqueous enzyme catalysis should be proposed urgently.

This topic aims to cover the enzyme immobilization technologies for efficient industrial biocenology around enzymatic catalysis through immobilized enzymes, computational engineering, material technology, and scale up process application. We welcome original research articles, reviews, brief research reports, case reports, and perspectives. Topics of interest for this issue collection include, but are not limited to:
•Enzyme engineering and immobilization methods (e.g., immobilization strategies and material design engineering, etc.)
• Biosynthesis of bioproducts with improved enzyme.
• Computational simulation for designing immobilized enzymes.
• Bioprocess optimization in the top of immobilized enzymes.
• Unconventional and cascade enzymatic catalytic processes using free or immobilized enzymes (e.g. enzymatic catalysis in non-aqueous systems and multi-enzyme biocatalysis, etc.)
• Design of chemo/enzyme hybrid catalysts.
• Construction of metal/enzyme hybrid catalysts.
• Application of immobilized enzyme in industrial processes (e.g., biochemical synthesis, medical intermediate, biofuel, biosensor, enzymology medical, etc.)

Keywords: Innovative enzyme immobilization techniques, Bioprocess optimization, Chemo/enzyme hybrid catalysts, Self-assembly immobilization, Multi-enzyme co-immobilization, Catalysis of immobilized enzyme in non-aqueous systems, Metal/enzyme hybrid catalysts, Carrier-free immobilization, Hybrid nanoflowers, Application of immobilized enzyme in industrial processes

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