Diverse communication systems mediate intracellular communication, both in physiological and pathological conditions, such as cellular junctions (tight junction, adherence junctions, gap junctions, and desmosomes), integrins, and selectins. Recently, extracellular vesicles (EVs)-mediated cell-cell communication has gained much attention. EVs are a heterogeneous group of cell-derived membranous nanovesicles with sizes around 30-1000 nm, including exosomes, microvesicles, and apoptotic bodies. They are released from most cell types and biofluids. More and more studies have reported the crucial roles of EV-mediated communication in not only normal cellular processes including stem cell behaviors and organ development but also the malignant progression of cancer via autocrine, paracrine, and endocrine communications.
Intracellular communications including both conventional cellular communications and the novel EV-mediated crosstalk are major components in tissue microenvironment regulation. This Research Topic will focus on the functions of regular cellular communications and EVs in regulating normal cell processes and diseases. We are interested in understanding the cellular or molecular mechanisms about the intracellular communications in stem cell self-renewal and differentiation, niche regulation and maintenance of stem cell pool, cell fate determination and organogenesis. In cancer, they are involved in cancer initiation and progression, cell migration and proliferation, epithelial-mesenchymal transition (EMT), induction of angiogenesis, inflammatory responses, immune suppression, escape from immune surveillance, and metastasis. Furthermore, the ability of EVs to carry different cargoes including drug and molecular information to the recipient cells make them a novel tool for molecular engineering, development of biomaterials and therapeutics.
The Research Topic covers, but is not limited to, the following:
• Roles of EVs and intracellular crosstalk in normal stem cells or cancer stem cells.
• EV-mediated communication in organ development
• Intracellular communication in normal cell processes including proliferation, apoptosis, and senescence; and the novel signaling between donor and receipt cells.
• EVs and intracellular crosstalk in cancer initiation, progression and metastasis.
• EVs and intracellular crosstalk in cancer immunology and immunotherapy.
• Application of EVs as a diagnostic and therapeutic tool.
• Application of EVs as biomaterial and drug deliver.
• Technological advancements in EV research.
Diverse communication systems mediate intracellular communication, both in physiological and pathological conditions, such as cellular junctions (tight junction, adherence junctions, gap junctions, and desmosomes), integrins, and selectins. Recently, extracellular vesicles (EVs)-mediated cell-cell communication has gained much attention. EVs are a heterogeneous group of cell-derived membranous nanovesicles with sizes around 30-1000 nm, including exosomes, microvesicles, and apoptotic bodies. They are released from most cell types and biofluids. More and more studies have reported the crucial roles of EV-mediated communication in not only normal cellular processes including stem cell behaviors and organ development but also the malignant progression of cancer via autocrine, paracrine, and endocrine communications.
Intracellular communications including both conventional cellular communications and the novel EV-mediated crosstalk are major components in tissue microenvironment regulation. This Research Topic will focus on the functions of regular cellular communications and EVs in regulating normal cell processes and diseases. We are interested in understanding the cellular or molecular mechanisms about the intracellular communications in stem cell self-renewal and differentiation, niche regulation and maintenance of stem cell pool, cell fate determination and organogenesis. In cancer, they are involved in cancer initiation and progression, cell migration and proliferation, epithelial-mesenchymal transition (EMT), induction of angiogenesis, inflammatory responses, immune suppression, escape from immune surveillance, and metastasis. Furthermore, the ability of EVs to carry different cargoes including drug and molecular information to the recipient cells make them a novel tool for molecular engineering, development of biomaterials and therapeutics.
The Research Topic covers, but is not limited to, the following:
• Roles of EVs and intracellular crosstalk in normal stem cells or cancer stem cells.
• EV-mediated communication in organ development
• Intracellular communication in normal cell processes including proliferation, apoptosis, and senescence; and the novel signaling between donor and receipt cells.
• EVs and intracellular crosstalk in cancer initiation, progression and metastasis.
• EVs and intracellular crosstalk in cancer immunology and immunotherapy.
• Application of EVs as a diagnostic and therapeutic tool.
• Application of EVs as biomaterial and drug deliver.
• Technological advancements in EV research.