Cancer has posed a tremendous threat to the health of human beings worldwide, and an increasing number of people die of cancer every year. Great efforts have been devoted to developing new therapeutic modalities for cancer treatment. Phototherapy, including photodynamic and photothermal therapy, utilizes the photogeneration of reactive oxygen species (ROS) or heat to induce cell apoptosis. Solid tumors usually suffer from hypoxia which is strongly associated with tumor propagation, malignant progression, and resistance to therapy. However, several factors limit the widespread clinical use of photodynamic therapy (PDT), such as O2 shortage induced hypoxia and insufficient tissue penetration depth. Therefore, new intelligent photosensitizers should be designed and synthesized to achieve better phototherapeutic efficacy.
The scope of the Research Topic includes but is not limited to:
• Designing novel photosensitizer to relieve hypoxia by different methods, for example, delivering oxygen to the tumor or in situ generation oxygen;
• Diminishing oxygen consumption with oxygen-independent therapy, for example, type I PDT;
• Synthesizing X-ray responsive radiosensitizers with limitless penetration;
• Designing self-illuminating photosensitizers without external laser irradiation.
• Inhibiting tumor recurrence and metastasis by photo-immunotherapy.
This Research Topic will attract extensive interest from researchers who want to seek new therapeutic methods for better understanding the relationship between the structure and therapeutic efficacy. The knowledge generated here will not only benefit the research communities of synthetic chemistry and biomaterials but also add to the understanding of cancer treatment for pre-clinical application. All article types are accepted, including communication, research paper, perspective, and review.
Cancer has posed a tremendous threat to the health of human beings worldwide, and an increasing number of people die of cancer every year. Great efforts have been devoted to developing new therapeutic modalities for cancer treatment. Phototherapy, including photodynamic and photothermal therapy, utilizes the photogeneration of reactive oxygen species (ROS) or heat to induce cell apoptosis. Solid tumors usually suffer from hypoxia which is strongly associated with tumor propagation, malignant progression, and resistance to therapy. However, several factors limit the widespread clinical use of photodynamic therapy (PDT), such as O2 shortage induced hypoxia and insufficient tissue penetration depth. Therefore, new intelligent photosensitizers should be designed and synthesized to achieve better phototherapeutic efficacy.
The scope of the Research Topic includes but is not limited to:
• Designing novel photosensitizer to relieve hypoxia by different methods, for example, delivering oxygen to the tumor or in situ generation oxygen;
• Diminishing oxygen consumption with oxygen-independent therapy, for example, type I PDT;
• Synthesizing X-ray responsive radiosensitizers with limitless penetration;
• Designing self-illuminating photosensitizers without external laser irradiation.
• Inhibiting tumor recurrence and metastasis by photo-immunotherapy.
This Research Topic will attract extensive interest from researchers who want to seek new therapeutic methods for better understanding the relationship between the structure and therapeutic efficacy. The knowledge generated here will not only benefit the research communities of synthetic chemistry and biomaterials but also add to the understanding of cancer treatment for pre-clinical application. All article types are accepted, including communication, research paper, perspective, and review.