Inflammation and aging are both physio-pathological processes associated with the development of different chronic-degenerative diseases, including tumors and neurological disorders. Both processes are strictly correlated as the new term 'inflammaging' has been coined. Indeed, inflammaging means a chronic and systemic low-grade inflammatory process increasing with aging potentially associated with different pathologies. Therefore, it is evident how a better knowledge on inflammaging as well as the developing of novel therapeutic strategies aimed at reducing inflammation during aging are mandatory to effectively manage age- and inflammation-related diseases.
On these bases, the aim of the present Research Topic is to review the molecular and cellular determinants responsible for the increasing levels of inflammatory markers as well as the role of aging in the onset of chronic-degenerative diseases. The Research Topic aims also to collect up-to-date knowledge on already approved or future therapeutic strategies available for the treatment of aging-related inflammation as well as studies on epigenetic factors associated with inflammaging and useful as diagnostic and prognostic biomarkers.
We welcome original research, case reports, meta-analysis and review articles. Potential topics will include but are not limited to:
1. Molecular determinants of inflammation and ageing;
2. Inflammation and aging in the development of tumors;
2. Inflammation and aging in the development of neurodegenerative;
3. Inflammaging and novel therapies;
4. Novel epigenetic therapeutic strategies in inflammation and aging;
5. Epigenetic mechanisms and strategies to overcome drug resistance in chronic-degenerative diseases;
6. DNA methylation hotspots as an early marker of brain tumors development.
Inflammation and aging are both physio-pathological processes associated with the development of different chronic-degenerative diseases, including tumors and neurological disorders. Both processes are strictly correlated as the new term 'inflammaging' has been coined. Indeed, inflammaging means a chronic and systemic low-grade inflammatory process increasing with aging potentially associated with different pathologies. Therefore, it is evident how a better knowledge on inflammaging as well as the developing of novel therapeutic strategies aimed at reducing inflammation during aging are mandatory to effectively manage age- and inflammation-related diseases.
On these bases, the aim of the present Research Topic is to review the molecular and cellular determinants responsible for the increasing levels of inflammatory markers as well as the role of aging in the onset of chronic-degenerative diseases. The Research Topic aims also to collect up-to-date knowledge on already approved or future therapeutic strategies available for the treatment of aging-related inflammation as well as studies on epigenetic factors associated with inflammaging and useful as diagnostic and prognostic biomarkers.
We welcome original research, case reports, meta-analysis and review articles. Potential topics will include but are not limited to:
1. Molecular determinants of inflammation and ageing;
2. Inflammation and aging in the development of tumors;
2. Inflammation and aging in the development of neurodegenerative;
3. Inflammaging and novel therapies;
4. Novel epigenetic therapeutic strategies in inflammation and aging;
5. Epigenetic mechanisms and strategies to overcome drug resistance in chronic-degenerative diseases;
6. DNA methylation hotspots as an early marker of brain tumors development.