About this Research Topic
Exercise plays an imperative role in maintaining or improving health status. The positive benefits of exercise are believed to be, at least partly, mediated by tissue crosstalk. In this interorgan crosstalk, numerous tissues are known to be responsible for the release proteins or other bioactive molecules. The recent discovery of extracellular vesicles (EVs), being membranous cargo carriers involved in transporting a wide range of bioactive compounds in biological fluids, has also gained interest in the field of metabolism and exercise physiology. Therefore, unraveling the potential of EVs in the multi-systemic, adaptive response to exercise and exercise training might be an exciting challenge to further elucidate the heterogeneity in interorgan crosstalk.
The introduction of EVs is quite novel, with only a limited number of research papers in the field of metabolism and exercise physiology. Moreover, the contribution of the tissue-specific EVs in the metabolic and physiological adaptations to exercise has rarely been studied. It also needs to be determined which type of exercise (aerobic vs resistance vs high intensity interval) or which exercise characteristics (duration, frequency, intensity) favour the secretion of EVs by different metabolic tissues. This Research Topic will gather the latest insights in the role of EVs in interorgan crosstalk during acute or chronic exercise interventions in health and (cardiometabolic) disease states.
The aim of this Research Topic is to provide a platform for original research and review articles that shed more light on the release of EVs during acute exercise and their role in the adaptations to chronic exercise training. We encourage interested experts (scientists, clinicians, and exercise specialists) to submit their contributions with a specific focus on:
• cellular and molecular mechanisms of exercise-induced EVs in tissue-specific adaptations to achieve health-promoting effects.
• the role of acute/chronic exercise characteristics in the release of EVs by metabolic tissues such as skeletal muscle, adipose tissue, liver and cardiac tissue.
• understanding the role of circulating EVs in the physiological and metabolic adaptations to exercise interventions.
The introduction of EVs is quite novel, with only a limited number of research papers in the field of metabolism and exercise physiology. Moreover, the contribution of the tissue-specific EVs in the metabolic and physiological adaptations to exercise has rarely been studied. It also needs to be determined which type of exercise (aerobic vs resistance vs high intensity interval) or which exercise characteristics (duration, frequency, intensity) favour the secretion of EVs by different metabolic tissues. This Research Topic will gather the latest insights in the role of EVs in interorgan crosstalk during acute or chronic exercise interventions in health and (cardiometabolic) disease states.
The aim of this Research Topic is to provide a platform for original research and review articles that shed more light on the release of EVs during acute exercise and their role in the adaptations to chronic exercise training. We encourage interested experts (scientists, clinicians, and exercise specialists) to submit their contributions with a specific focus on:
• cellular and molecular mechanisms of exercise-induced EVs in tissue-specific adaptations to achieve health-promoting effects.
• the role of acute/chronic exercise characteristics in the release of EVs by metabolic tissues such as skeletal muscle, adipose tissue, liver and cardiac tissue.
• understanding the role of circulating EVs in the physiological and metabolic adaptations to exercise interventions.
Keywords: extracellular vesicles exercise interorgan crosstalk metabolism adipose tissue skeletal muscle liver pancreas cardiac tissue
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
