About this Research Topic
The biomaterials scaffolds can be naturally derived and synthesized organic, inorganic, metallic, and hybrid materials. To facilitate precise tissue engineering, biomaterials can be further bio-functionalized by various bioactive agents. Bioactive agents can be naturally derived or synthetic cytokines, growth factors, extracellular vesicles, small-molecules, and peptides with one or multiple functions, such as osteoinduction, osteoconduction, anti-inflammation, anti-cancer, and anti-osteoclast. The methods to integrate bioactive agents into implants include internal incorporation, electrostatic deposition, surface modification, and entrapment.
This Research Topic focuses on both basic and applied research on the bio-functionalized biomaterial scaffolds with various bioactive agents to promote the regeneration of tissues and restore the functions of tissues and/or organs. The topic welcomes, but is not limited to e.g. Original Research, Reviews, Mini Reviews, the following research areas:
1) Design, development, and evaluation of novel bioactive agents for tissue engineering
2) New application of bioactive agents to functionalize biomaterial scaffolds
3) Development and characterization of bio-functionalization techniques for biomaterial scaffolds
4) Application of bioactive agents to promote cells-scaffold interactions for tissue regeneration
5) Advanced systems based on functional biomaterials and stem cells
Keywords: bioactive agents, tissue engineering, biomaterials, cell-scaffold interaction
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