About this Research Topic
Multiple questions remain to be answered in our efforts to develop an effective gene correction strategy to treat CF and other genetic diseases affecting the airways. In this Research Topic, we will present studies that advance the use of genome editing to treat CF and other diseases affecting the airways. These articles will focus on the genome modification of airway stem cells, delivery of genome editing reagents into the airways and approaches to correct CF causing mutations. We will also present reviews/perspectives on the development of gene therapy and genome editing for CF and other airway diseases.
We encourage submissions in the form of Original Research, Methods, Reviews, Mini Review, Opinion, and Hypothesis and Theory. Suitable topics include, but are not limited to:
· Genome editing (Homologous recombination (HR) or non-homologous end-joining (NHEJ) based) to correct or model CF causing mutations in any cell type
· Genome editing (HR or NHEJ based) based strategy to treat any airway disease
· Base and Prime Editing tools targeting CF in any organ or other airway diseases
· Enhancement/optimization of current approaches to precise gene editing in airway cells
· Understanding of homology directed repair (HDR) mechanisms in the context of gene correction and gene addition in airway cells
· In vivo delivery of genome editing reagents (e.g. Cas9 RNP, mRNA, other nucleases) to the airways
Keywords: Cystic fibrosis (CF), Genome editing to treat CF, Airway stem cell therapy, In vivo genome editing for CF, Genome engineering airway stem cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.