About this Research Topic
Musculoskeletal disorders may adversely affect the function and overall effectiveness of the musculoskeletal system and can be detrimental to the body. The musculoskeletal system consists of bones (the skeletal system), muscles (muscular system), cartilage, tendons, ligaments, joints, and other connective tissue providing support, stability, and movement to the body. Musculoskeletal disorders include osteoporosis, osteoarthritis, sarcopenia, and tendinopathy. They are very common afflictions that affect large populations of people. Particularly with increasing age, musculoskeletal tissues start to show increased bone fragility, loss of cartilage resilience, reduced ligament elasticity, loss of muscle mass and strength, and fat redistribution decreasing the ability of the tissues to carry out their normal functions. The loss of mobility and physical independence from such diseases can have tremendous physical and psychological effects in populations leading to increased mortality rates.
Promising progress in the pharmaceuticals and treatments available for musculoskeletal disorders have been made in the last decades, especially in the pain management and tissue regeneration. However, there is still a large knowledge gap between the clinical demands and the basic research in this field. Translational research has great potential in bridging the gap between benchside and bedside. This Research Topic aims to highlight translational studies looking at novel drugs and therapeutic substances for the treatment and prevention of musculoskeletal diseases promoting tissue regeneration. The articles within this collection will also help advance the understanding of mechanisms that initiate musculoskeletal diseases. To achieve this we would like to explore the advanced technologies in drug delivery, targeting methods, release kinetics and distributions in the musculoskeletal system.
For this Research Topic, our prime focus would be on the translation of novel therapeutic substances for the treatment of musculoskeletal disorders. We welcome Original Research and Review articles focused on, but are not limited to, the preclinical assessments of novel therapeutic or preventive treatments for the musculoskeletal disorders and mechanistic studies that help in understanding the musculoskeletal diseases.
Topic Editor Sien Lin received financial support from Natural Science Foundation of China, Human Resources and Social Security Department of Guangdong Province and Natural Science Foundation of Guangdong Province as a PI. He was also a Co-PI receiving financial support from the Research Grant Council Hong Kong and the Health and Medical Research Fund. The other Topic Editors declare no competing interests with regard to their Research Topic subject.
Promising progress in the pharmaceuticals and treatments available for musculoskeletal disorders have been made in the last decades, especially in the pain management and tissue regeneration. However, there is still a large knowledge gap between the clinical demands and the basic research in this field. Translational research has great potential in bridging the gap between benchside and bedside. This Research Topic aims to highlight translational studies looking at novel drugs and therapeutic substances for the treatment and prevention of musculoskeletal diseases promoting tissue regeneration. The articles within this collection will also help advance the understanding of mechanisms that initiate musculoskeletal diseases. To achieve this we would like to explore the advanced technologies in drug delivery, targeting methods, release kinetics and distributions in the musculoskeletal system.
For this Research Topic, our prime focus would be on the translation of novel therapeutic substances for the treatment of musculoskeletal disorders. We welcome Original Research and Review articles focused on, but are not limited to, the preclinical assessments of novel therapeutic or preventive treatments for the musculoskeletal disorders and mechanistic studies that help in understanding the musculoskeletal diseases.
Topic Editor Sien Lin received financial support from Natural Science Foundation of China, Human Resources and Social Security Department of Guangdong Province and Natural Science Foundation of Guangdong Province as a PI. He was also a Co-PI receiving financial support from the Research Grant Council Hong Kong and the Health and Medical Research Fund. The other Topic Editors declare no competing interests with regard to their Research Topic subject.
Keywords: Musculoskeletal diseases, translational medicine, preventive and therapeutic drugs, mechanistic research, preclinical research
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