About this Research Topic
The kidneys and heart have a close relationship and share several functions in order to maintain the organism's homeostasis. The injury caused by renal dysfunctions to the heart or vice versa are treated in the literature as Cardiorenal Syndrome. Although it is known that kidney injuries can cause cardiac dysfunction as presented in SCR types 3 and 4, the mechanisms that lead to an increase in cardiovascular complications among patients (CKD) due to the retention of uremic toxins such as Indoxyl sulfate or P-Cresyl Sulfate, are not completely understood.
Studies related to retention of uremic compounds and their potential deleterious effects on the heart, whether in morphology or function, are still scarce and require further research and investigation. Thus, the present Research Topic aims to group several studies regarding research on uremic compounds and the development of cardiorenal syndrome.
This article collection aims to gather original scientific studies or reviews that may contribute to the theme related to the role of uremic compounds in renal and cardiac landings observed in cardiorenal syndrome.
Keywords: cardiorenal syndrome, inflammation, immune system, uremic compounds
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