About this Research Topic
Aging is accompanied with the dysregulation of various tissues. Different cells in tissues interact with each other constructing a steady microenvironment under physiological conditions. Tissues are composed of parenchymal cells and accessory cells, which regulate the normal function of tissues. In different tissues, parenchymal cells have unique functions due to cell differentiation. Accessory cells, such as immune cells and stromal cells, support the core function of parenchymal cells.
Cellular senescence is an irreversible process organism age. The existence of cell cycle withdraw, macromolecular damage, dysregulated metabolism, and senescence-associated secretory phenotype (SASP) are hallmarks of cellular senescence. The role of senescent cells in various tissues is intriguing. Cellular senescence not only leads to the dysfunction of senescent cells, but also affects other cells in the microenvironment through SASP. How senescent cells in different tissues interact with other cells and result in the dysregulation of tissues is an interesting topic. Besides, the paracrine effects of senescent cells cause normal surrounding cells to become senescent. However, which component in different tissues triggers the cellular senescence in various cells and consequently dysregulated tissues is also ambiguous.
In this Research Topic, we are welcoming original research articles and review articles that investigate the role of cellular senescence and cellular communications within tissue microenvironments during aging.
We welcome articles on the following sub-questions or sub-topics:
1. What in tissue microenvironments triggers cellular senescence and consequently the organism's aging and diseases during aging?
2. How senescent cells in different tissues interact with other cells and result in the organism's aging and diseases?
3. What are the underlying mechanisms of cellular senescence and cellular communications within tissue microenvironments, such as metabolic regulation, immune regulation, and endocrine regulation, et al?
4. How to target cellular senescence and cellular communications within tissue microenvironments to prevent age-related diseases, including cardiovascular diseases, cancer, neurological diseases and other diseases?
Topic Editor Dr. Evandro Fei Fang has CRADA arrangements with ChromaDex, and is a consultant to Aladdin Healthcare Technologies and the Vancouver Dementia Prevention Centre. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Cellular senescence is an irreversible process organism age. The existence of cell cycle withdraw, macromolecular damage, dysregulated metabolism, and senescence-associated secretory phenotype (SASP) are hallmarks of cellular senescence. The role of senescent cells in various tissues is intriguing. Cellular senescence not only leads to the dysfunction of senescent cells, but also affects other cells in the microenvironment through SASP. How senescent cells in different tissues interact with other cells and result in the dysregulation of tissues is an interesting topic. Besides, the paracrine effects of senescent cells cause normal surrounding cells to become senescent. However, which component in different tissues triggers the cellular senescence in various cells and consequently dysregulated tissues is also ambiguous.
In this Research Topic, we are welcoming original research articles and review articles that investigate the role of cellular senescence and cellular communications within tissue microenvironments during aging.
We welcome articles on the following sub-questions or sub-topics:
1. What in tissue microenvironments triggers cellular senescence and consequently the organism's aging and diseases during aging?
2. How senescent cells in different tissues interact with other cells and result in the organism's aging and diseases?
3. What are the underlying mechanisms of cellular senescence and cellular communications within tissue microenvironments, such as metabolic regulation, immune regulation, and endocrine regulation, et al?
4. How to target cellular senescence and cellular communications within tissue microenvironments to prevent age-related diseases, including cardiovascular diseases, cancer, neurological diseases and other diseases?
Topic Editor Dr. Evandro Fei Fang has CRADA arrangements with ChromaDex, and is a consultant to Aladdin Healthcare Technologies and the Vancouver Dementia Prevention Centre. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
