About this Research Topic
Goal: The major challenges for clinicians and researchers in onco-endocrinology is to identify and characterize the CSCs in each type of ET and to dissect the mechanisms by which CSCs regulate tumor development and progression in order to identify potential biomarkers of the response to therapies and chemoresistance. Accordingly, it is urgently needed to better clarify the biology of ET-specific CSC populations to develop innovative CSC-targeted and more efficacious anti-tumor strategies.
Scope: Given the clinical impact of CSCs in cancer progression, the aim of this Research Topic is to provide a comprehensive picture of this cancer cell subpopulation in a variety of ETs and touching multiple aspects (origin, role in cancer progression, cross-talk with the tumor microenvironment, genetic and/or epigenetic reprogramming, druggable deregulated pathways, identification of diagnostic/prognostic biomarkers, sensitivity to novel drugs), pivotal for a better understanding of ETs, with particular attention to the potential therapeutic implications.
Details for Authors: Authors involved in the study of CSCs in ETs are welcomed to submit their work, including Original Research, Methods, Protocols, Review, Mini Review, Systematic Review, Perspective, Clinical Trial and Opinion.
Keywords: CSCs, EMT, Microenvironment, Genetics and Epigenetics, Target Therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.