Molecular Mechanisms Controlling the Metabolic Reprogramming of Immune Cells Under Pathophysiological Conditions

The adaptive and innate immune systems are comprised of a heterogeneous group of cells, which normally exist in an inactive state. However, they all possess the ability to become rapidly activated in response to invading pathogens and foreign material. There is now a growing appreciation that the switch from a resting state to an active state is associated with numerous metabolic changes. In addition, not only are the metabolic programs utilized by quiescent and activated immune cells distinct but they also differ based on the metabolic demands of their effector states. These metabolic changes not only determine the function and fate of immune cells but also contribute to the pathogenesis of numerous diseases including; cancer, infection, diabetes, atherosclerosis, cardiovascular and inflammatory diseases.

In recent years, the molecular mechanisms linking immune cell activation and metabolic reprogramming have been explored. While the precise mechanisms remain to be fully elucidated both cell-specific and common transcriptional pathways e.g. HIF are emerging. As this is a recent and rapidly evolving area of research, this Research Topic aims to provide a comprehensive overview of our current understanding of the molecular pathways controlling the metabolic reprogramming of immune cells under pathophysiological conditions. The broad spectrum of discussion with the adaptive and innate immune systems will open-up new avenues of research to explore and could offer exciting opportunities for the development of novel therapeutic and diagnostic strategies for numerous diseases