About this Research Topic
Induced pluripotent stem cell (iPSCs) are somatic cells reprogrammed into a pluripotent stem cell state by the expression of key transcriptional factors. Human iPSCs resemble many pluripotent properties of embryonic stem cells (ESCs), including the nearly unlimited self-renewal capacity and ability to differentiate into cells of all three germ layers. In contrast to ESCs, iPSCs can be derived from a patient's somatic cells, which overcomes concerns of immune rejection and the destruction of embryos. The iPSCs is thereby a promising patient-specific cell source for tissue engineering regenerative medicine.
This Research Topic is focusing on the state-of-the-art in biomaterials that advance iPSC-based tissue engineering technology for the creation of regenerative and therapeutic products. It will cover a wide spectrum of research subjects including (but will not be limited to):
- novel biomaterials for safe, efficient, and scalable iPSC reprogramming
- biomaterials and bioreactors designed for optimal in vitro iPSC expansion and differentiation
- ex vivo iPSC-derived disease model and high-throughput platform for epigenetic regulation
- functional tissue grafts consisting of biomaterials and differentiated iPSCs
- biomaterial strategies that drive iPSC-based pre-vascularization.
Photocredit: Andrew Agbay
This Research Topic is focusing on the state-of-the-art in biomaterials that advance iPSC-based tissue engineering technology for the creation of regenerative and therapeutic products. It will cover a wide spectrum of research subjects including (but will not be limited to):
- novel biomaterials for safe, efficient, and scalable iPSC reprogramming
- biomaterials and bioreactors designed for optimal in vitro iPSC expansion and differentiation
- ex vivo iPSC-derived disease model and high-throughput platform for epigenetic regulation
- functional tissue grafts consisting of biomaterials and differentiated iPSCs
- biomaterial strategies that drive iPSC-based pre-vascularization.
Photocredit: Andrew Agbay
Keywords: biomaterials, induced pluripotent stem cell, bioreactor, nanotechnology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
