About this Research Topic
A key step in cell division is the partitioning of the chromosomes into the newly created daughter cells. Errors in chromosome segregation can lead to cancer, infertility, and developmental disorders.
Chromosome segregation, and the subsequent division of the cell, involves diverse cellular and intracellular motions. For example, chromosomes condense into a rod-like shape, centrosomes, and migrate over several microns to properly position in the cell, and cytoskeletal actin and microtubules organize into structures that segregate chromosomes and divide the cell into two. Cell division thus involves a precise control over numerous types and numbers of molecular activities in space, and individual division steps are tightly coordinated in time. Understand the mechanisms behind this dynamic yet highly-ordered process requires the integration of molecular, cell biological, biophysical, structural, engineering, and biochemical studies.
In this Research Topic, we aim to bring together researchers investigating mechanisms of cell division using various model systems and employing diverse experimental and theoretical approaches. Our primary focus will be on the architecture, mechanics, and dynamics of cell division, but will not be limited to only these aspects. Article types can be either Original Research or Reviews. We believe that this topic will enable the community to share the most up-to-date views on cell division, and lead to new ideas which will help to understand this essential cellular process.
Chromosome segregation, and the subsequent division of the cell, involves diverse cellular and intracellular motions. For example, chromosomes condense into a rod-like shape, centrosomes, and migrate over several microns to properly position in the cell, and cytoskeletal actin and microtubules organize into structures that segregate chromosomes and divide the cell into two. Cell division thus involves a precise control over numerous types and numbers of molecular activities in space, and individual division steps are tightly coordinated in time. Understand the mechanisms behind this dynamic yet highly-ordered process requires the integration of molecular, cell biological, biophysical, structural, engineering, and biochemical studies.
In this Research Topic, we aim to bring together researchers investigating mechanisms of cell division using various model systems and employing diverse experimental and theoretical approaches. Our primary focus will be on the architecture, mechanics, and dynamics of cell division, but will not be limited to only these aspects. Article types can be either Original Research or Reviews. We believe that this topic will enable the community to share the most up-to-date views on cell division, and lead to new ideas which will help to understand this essential cellular process.
Keywords: microtubules, actin, forces, microscopy, mitosis, meiosis, spindles, abscission, contractile ring, cytokinesis, motor proteins
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