About this Research Topic
In immune cells, UPR molecular effectors are also involved in regulating physiological functions such as cell differentiation, survival, and immunoglobulin and cytokine production. Recently, the UPR machinery has been shown to modulate the maturational program and the antigen presentation capacities of dendritic cells. Taken together, it is now evident that the UPR plays an important role in orchestrating a variety functions of the immune system, both as part of normal immune cell physiology as well as in the modulation of established immune responses.
In this Research Topic we aim to look at the recent advances in our understanding of the mechanisms and significance of ER stress and the UPR in immunity. We welcome the submission of high-quality Original Research, Brief Research Reports, Reviews and Mini-Reviews covering, but not limited to, the following topics:
1. The role of UPR effectors in immune cell homeostasis.
2. ER stress and UPR effectors in immune cell dysfunction.
3. ER stress in infection and chronic inflammatory diseases.
4. ER stress in the breaking of immune tolerance: involvement in the pathogenesis of autoimmune diseases.
5. ER stress as a trigger/enhancer of inflammation in neuropathologies, neurodegenerative and psychiatric diseases.
6. UPR effectors as new pharmacological targets for the modulation of inflammatory/immune responses.
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