About this Research Topic
It is well-recognised that RdRps have a catalytic core that is conserved at a structural level and, to a lesser extent, at a sequence level. This has already led to invaluable insights into structure-function relationships. Recent structures, from e.g. the negative strand RNA viruses, have also shown how the conserved RdRp core is integrated into the viral transcription and replication activities through auxiliary domains and the motions of these domains. Other recent work has focused on the kinetics and dynamics of the RdRp using single-molecule experiments and molecular dynamics simulations, while yet further work has shown how RdRp function is linked to host adaptation and virulence.
In this Rresearch Ttopic, we aim to bring together our most up-do-date understanding of RdRp function and are looking to present a timely and comprehensive overview of novel insights into:
- RdRp structure and dynamics
- The interaction of RdRp with viral RNA
- RdRp fidelity and viral genome mutation
- Interactions of the RdRp with host factors
- The RdRp as target in antiviral strategies
Keywords: RNA-dependant RNA polymerase, virus, structure, pathogenesis, vaccine
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