About this Research Topic
Many questions remain unanswered regarding the immune responses in nervous system tumors and their specific cellular responses. For example, what types of microglia-macrophage phenotypes exist in neoplastic environments within the nerve tissue? Are they functional phagocytic cells? More generally, do other immune cells, such as T cells, retain function in a neoplastic environment in nerve tissue? Is antigen presentation affected and what are the checkpoints preventing induction of immune responses? Other important areas that need to be addressed include the immune mechanisms invoked by therapies, modification of the tumor environmental and the overriding importance of innate versus adaptive immune responses.
In this Frontiers Research Topic, we intend to compile articles where we can come closer to settle down some of these questions. Especially covering different types of tumors hosted in the nerve tissue. We then expect to display the array of distinctive immune responses occurring in the cancers of the nervous system and shed some light to researchers and clinicians that are currently planning or evaluating clinical trials, or designing new therapeutic tools for these types of cancers.
We are particularly interested in manuscripts reporting evidences of the alterations of the immune responses in nervous system tumors, especially obtained from biopsies of patients and from well-established experimental models. Studies showing cellular and molecular characteristics of immune cells innate and adaptive responses in nerve tissue tumors will be prioritized. In addition, preclinical studies of immune-based therapeutics will also be of choice. Data from both clinical and basic studies are welcome for submissions. Both review articles and original scientific papers will be considered for publication.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.