About this Research Topic
Many risk factors have been studied as a pre-disposing factor in the development of this cancer, but only for some there is a high level of evidence. In recent times, progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular cancer, suggested a common foetal origin. The central hypothesis of this observation asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity during embryogenesis, are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to endocrine environment influencing testicular development during foetal life.
The objective of this Research Topic is to group a collection of manuscripts focused on new and more recent insights about TGCT. In particular, our aim is to involve a large number of experts coming from different areas of medicine (endocrinology, andrology, oncology, genetic, psychology) in the production of original articles, reviews or mini-reviews on TGCT. We suggest the submission of abstracts with the following proposals: origins of TGCT, genetic causes, treatments for TGCT and possible side effects, sexual function and general health in TGCT survivors, fertility and fertility preservation.
Keywords: Cancer Therapies, Hypogonadism, Male Infertility, Sexual Function, Testicular Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.