About this Research Topic
This Research Topic will be focused on peripheral nerve regeneration and on the strategies to promote and improve it, paying attention not only to the injured nerve, but also to the target organs, and to the strategies to combat muscle atrophy due to prolonged denervation or to recover the lost sensitivity. The role of different cell populations in the peripheral nerve regeneration will be considered, including not only different Schwann cell phenotypes (“repair”, myelinating, non myelinating, etc…) and neurons (sensitive, motoneurons, … ), but also epineurial cells, macrophages, and so on. Different genes involved in nerve regeneration will be considered not only with regard to the expression level of messenger RNA and proteins, but also regarding the microRNAs regulating their expression. To promote neuronal survival, axonal regeneration and target reinnervation, different strategies are considered, including the use of innovative biomaterials and implantable scaffolds, gene therapy, optogenetics, tissue engineering, pharmacological approaches, cell-based therapies. Attention will be payed to new achievements for clinical application, new pre-clinical concepts , and to appropriate experimental methods for the assessment of functional recovery, and for accurate morphological and biomolecular analyses. Also, new experimental models to study the different neuropathies will be presented, with a particular attention to in vitro models to avoid or reduce the use of animals.
We invite authors to submit Original Research Articles or Reviews aligned to the research fields outlined above and qualified to advance the field a step forward in translating basic neuroscience knowledge into novel therapeutic strategies.
Keywords: regeneration, peripheral nerve repair, neuropathies, Schwann cells, target organ reinnervation, functional recovery
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.