About this Research Topic
In this Research Topic, we aim to discuss NFAT1 to 4 and NFAT5 control of rheumatoid inflammation and other autoimmune diseases in the context of recent therapeutic developments. We welcome the submission of articles covering the following topics:
1. Overview of NFAT1 to 4 and NFAT5 including:
1.1. Gene, protein, molecular structure of NFAT1 to 4 and NFAT5.
1.2. Expression and regulation of NFAT1 to 4 and NFAT5 in different tissues.
1.3. Biologic functions of NFAT1 to 4 and NFAT5.
2. The role of calcium-mediated signaling in the pathogenesis of autoimmune and inflammatory diseases including:
2.1. Essential role of NFAT1 to 4 in the activation of lymphocytes, myeloid cells and osteoclasts.
2.2. Role of NFAT1 to 4 in health and diseases.
2.3. Deregulation of calcium, calcineurin, and NFAT1 to 4 pathways in RA and other autoimmune diseases.
3. Regulation of Calcineurin-NFAT1 to 4 signaling for treatment for autoimmune diseases:
3.1. Deregulation of calcium, calcineurin, and NFAT1 to 4 pathways in RA pathogenesis.
3.2. Mode of action, efficacy, and safety of Cyclosporine A and Tacrolimus for active RA.
3.3. Revisit to calcineurin inhibitors with therapeutic advancement in autoimmune diseases; 3.4. Drug repurposing for the treatment of lupus, autoimmune nephropathy, and Sjögren's syndrome.
4. Role of NFAT5 in the immune system and pathogenesis of autoimmune and inflammatory diseases:
4.1. High salt and Th17 polarity.
4.2. High salt regulation of innate immunity.
4.3. Role of NFAT5 for cartilage integrity.
4.4. Tonicity-independent role of NFAT5 in innate immunity, including macrophage activation and survival.
4.5. Requirement of NFAT5 for the progression of chronic arthritis.
Keywords: NFAT, Rheumatoid arthritis, Autoimmunity
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