About this Research Topic
Promyelocytic leukemia (PML) protein is a tumor suppressor implicated in tumorigenesis in different tissues. PML is object of intense research on the basis of this premise.
A large number of alternative spliced transcripts are transcribed from the PML gene, resulting in a variety of PML proteins ranging in molecular weight. The different PML isoforms display a complex intracellular distribution while modulating diverse cellular functions such as transcription, DNA-damage response, sumoylation, cellular senescence, neoangiogenesis, differentiation and apoptosis.
PML exerts this pleiotropic role through its functionally interaction and with a large number of key proteins involved in these physiological process.
In this Research Issue, aimed at a comprehensive coverage of the PML field, we accept review articles, perspectives, research articles, Methods, Hypothesis & Theory covering any of the biological aspects involving this intriguing protein with functions not yet completely resolved.
A large number of alternative spliced transcripts are transcribed from the PML gene, resulting in a variety of PML proteins ranging in molecular weight. The different PML isoforms display a complex intracellular distribution while modulating diverse cellular functions such as transcription, DNA-damage response, sumoylation, cellular senescence, neoangiogenesis, differentiation and apoptosis.
PML exerts this pleiotropic role through its functionally interaction and with a large number of key proteins involved in these physiological process.
In this Research Issue, aimed at a comprehensive coverage of the PML field, we accept review articles, perspectives, research articles, Methods, Hypothesis & Theory covering any of the biological aspects involving this intriguing protein with functions not yet completely resolved.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
