Bridging Translational Gaps in Cardiovascular Disease Through Large Animal Research

About this Research Topic

Background

Large animal models are pivotal in the realm of preclinical cardiovascular research, offering critical insights that bridge foundational scientific discoveries with clinical applications. Their close physiological and pathological resemblance to humans makes them particularly valuable for the development, evaluation, and refinement of novel therapeutic interventions. This Research Topic is focused on the latest advancements in the utilization of large animal models for the study of cardiovascular diseases and the assessment of emerging therapeutic strategies.

Objective:

The primary aim of this Research Topic is to enhance our understanding of the applications, challenges, and innovations associated with the use of large animal models in cardiovascular research. By compiling original research, reviews, and perspectives, we aspire to foster a comprehensive overview of how these models are pivotal in translating basic research findings into actionable clinical practices, thereby improving patient care and treatment outcomes.

Scope of Research:

Model Development and Characterization:

o Development and validation of large animal models that closely mimic human cardiovascular diseases.

o Comparative analysis focusing on the cardiovascular physiology and pathology across various large animal models.

Pathophysiological Insights:

o Novel studies that reveal insights into the mechanisms of cardiovascular diseases through the use of large animal models.

o Examination of specific disease processes, such as atherosclerosis, heart failure, and arrhythmias, in these models.

Therapeutic Evaluations:

o Evaluation of the efficacy and safety of new drugs, devices, and surgical interventions within large animal models.

o Translational research studies that aim to bridge experimental therapies with human clinical trials.

Innovative Methodologies:

o Advances in imaging, monitoring, and data analysis techniques specifically tailored for large animal cardiovascular research.

o Innovative approaches aimed at increasing the relevance and reproducibility of findings from large animal studies.

Ethical and Practical Considerations:

o Discussion on ethical considerations and welfare standards critical to the use of large animals in research.

o Strategies to address and overcome practical challenges such as cost and logistical complexities inherent in large animal research.


Call for Contributions:

We invite researchers, clinicians, and professionals from related fields to submit original research articles, thorough reviews, and informed perspectives that address the outlined themes. This Research Topic intends to illuminate the crucial role of large animal models in closing the translational gap between laboratory research and clinical application, significantly advancing the field of cardiovascular therapy and improving overall patient outcomes.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Curriculum, Instruction, and Pedagogy
• Editorial
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Curriculum, Instruction, and Pedagogy
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Large Animal Models, Cardiovascular Disease, Therapeutic Evaluation, Translational Research, Atherosclerosis, Heart Failure, Arrhythmias, Imaging Techniques, Drug Testing, Surgical Interventions

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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