About this Research Topic
In molecular biology, RNA modifications were traditionally associated with static structural components like rRNAs and tRNAs. However, advancements such as antibody immunoprecipitation and next-generation sequencing have revealed a diverse spectrum of RNA modifications across eukaryotic genomes, highlighting their dynamic and widespread nature. These modifications are crucial in determining cell fate and promoting tissue regeneration. Although around 200 RNA modifications have been identified, in-depth understanding is limited to a dozen, revealing a significant gap in our knowledge despite their important role as post-transcriptional regulators.
This Research Topic seeks to deepen our understanding of RNA modifications to address pressing medical and biological challenges such as developmental disorders, aging, and various diseases. Emphasis will be placed on exploring both the fundamental translational applications of well-documented epitranscriptomic modifications—including m6A, m5C, m7G, ac4C, and m1A—and uncovering novel mechanisms through less-studied modifications.
We welcome articles addressing, but not limited to, the following themes:
• Biochemical and biological roles of nucleic acids and proteins in RNA modification
• Advances in RNA modification-based therapeutics for genetic and acquired diseases
• Gene regulation through RNA modification mechanisms
• Structural biology insights into RNA and its modifications
• RNA stability, turnover, editing, processing, transport, and localization
• Development and design of vectors for RNA-based therapeutic delivery
• Applications of gene-modifying agents in clinical settings
Contributions may focus on critical roles in stem cell differentiation, developmental biology, and metabolic disorders, guiding future research in this vibrant and transformative field of biology.
This Research Topic seeks to deepen our understanding of RNA modifications to address pressing medical and biological challenges such as developmental disorders, aging, and various diseases. Emphasis will be placed on exploring both the fundamental translational applications of well-documented epitranscriptomic modifications—including m6A, m5C, m7G, ac4C, and m1A—and uncovering novel mechanisms through less-studied modifications.
We welcome articles addressing, but not limited to, the following themes:
• Biochemical and biological roles of nucleic acids and proteins in RNA modification
• Advances in RNA modification-based therapeutics for genetic and acquired diseases
• Gene regulation through RNA modification mechanisms
• Structural biology insights into RNA and its modifications
• RNA stability, turnover, editing, processing, transport, and localization
• Development and design of vectors for RNA-based therapeutic delivery
• Applications of gene-modifying agents in clinical settings
Contributions may focus on critical roles in stem cell differentiation, developmental biology, and metabolic disorders, guiding future research in this vibrant and transformative field of biology.
Keywords: RNA Modification, Development, Metabolism, Inflammation and immunity, Disorders and diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
