About this Research Topic

Background

Genomic medicine has revolutionized gynecological oncology, offering unprecedented insights into the molecular drivers of cancerous growths and their progression. Innovative technologies like high-throughput sequencing and molecular profiling have transformed our understanding by identifying key genetic and epigenetic deviations that propel a range of gynecological cancers. However, the practical application of these genomic discoveries to clinical settings is still in its early stages, with ongoing challenges in understanding the impact of specific genomic changes on tumor behavior, resistance mechanisms, and patient prognosis. Recent studies underscore the need for further exploration of these molecular pathways to improve diagnosis and to enable the creation of more targeted treatment options.

The goal of this Research Topic is to amalgamate pioneering research that demystifies the genomic underpinnings of gynecological cancers and showcases emerging diagnostic and therapeutic approaches. We seek to compile work that not only deepens knowledge of cancer biology but also highlights novel clinical strategies that could be pivotal for enhancing patient care. Contributions from eminent scholars are expected to bridge the gap between bench research and bedside application, offering a richer comprehension of how new genomic information can be tactically used in oncology.

To enhance our understanding within this dynamic field, the scope of this Research Topic covers a wide array of pertinent topics focusing on genomic medicine applied to oncological contexts:
- Comprehensive analysis of genetic and transcriptomic data to trace cancer development and progression in gynecological cases.
- Discovery and validation of innovative biomarkers for improving early cancer detection and predictions of treatment responses.
- Advances in non-invasive assessments through liquid biopsy techniques for tracking tumor genetics and dynamics.
- Development and validation of precision medicine strategies targeted at specific genetic mutations and pathways.
- Assessments of the efficacy of targeted treatments both in clinical trials and preclinical studies.
- Examination of resistance to treatments and strategies to counteract such mechanisms.
- Integration of multiple omics technologies to delineate complex tumor profiles and their implications in cancer progression.
- Investigations into epigenetic alterations and their implications in the development and advancement of gynecological cancers.
- Utilization of bioinformatics and AI to craft predictive models and decision-making tools in oncology.
- Discussions on the ethical and logistical issues surrounding the integration of genomic data into patient management routines.

This collection aims to put forth a thorough exploration of how genomic innovations are being integrated into personalized management strategies for gynecological cancers, paving the way for future breakthroughs and refined patient outcomes.

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public omics databases that are not supplemented by relevant functional validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Genomic medicine, gynecological oncology, tumorigenesis, biomarkers, precision medicine, liquid biopsy, molecular-targeted therapy, multi-omics, bioinformatics, artificial intelligence, epigenetics.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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